产品详情

  • 产品名称：Human NRG4 (Pro-neuregulin-4, membrane-bound isoform) CLIA Kit (STJC0000445)

  • 产品型号：STJC0000445
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Human NRG4 (Pro-neuregulin-4, membrane-bound isoform) CLIA Kit (STJC0000445)
详情介绍：
Applications: CLIA
Reactivity: Human
Note: FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS.
Sensitivity: 0.09ng/mL
Detection Limit: 0.16~10ng/mL
Short Description: This human NRG4 kit is a highly sensitive in-vitro chemiluminescent immunoassay for the measurement of trace amounts of analytes.
Storage Instruction: If unopened the kit may be stored at 2-8°C for up to 1 month. If the kit will not be used within 1 month, store the components separately, according to the component table in the manual.
Assay Time: 3.5h
Detection: Chemiluminescence
Gene Symbol: NRG4
Gene ID: 145957
Uniprot ID: NRG4_HUMAN
Specificity: This kit recognizes Human NRG-4 in samples. No significant cross-reactivity or interference between Human NRG-4 and analogues was observed.
Sample Type: Serum, plasma and other biological fluids
Post Translational Modifications Proteolytic cleavage close to the plasma membrane on the external face leads to the release of the soluble growth factor form. Extensive glycosylation precedes the proteolytic cleavage.
Function Low affinity ligand for the ERBB4 tyrosine kinase receptor. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. Does not bind to the ERBB1, ERBB2 and ERBB3 receptors.
Protein Name Pro-Neuregulin-4 - Membrane-Bound Isoform
Pro-Nrg4 Cleaved Into - Neuregulin-4
Nrg-4
Database Links Reactome: R-HSA-1227986
Reactome: R-HSA-1236394
Reactome: R-HSA-1250196
Reactome: R-HSA-1250342
Reactome: R-HSA-1250347
Reactome: R-HSA-1251985
Reactome: R-HSA-1257604
Reactome: R-HSA-1963640
Reactome: R-HSA-1963642
Reactome: R-HSA-2219530
Reactome: R-HSA-5673001
Reactome: R-HSA-6785631
Reactome: R-HSA-6811558
Reactome: R-HSA-8847993
Reactome: R-HSA-8863795
Reactome: R-HSA-9664565
Reactome: R-HSA-9665686
Cellular Localisation Pro-Neuregulin-4
Membrane-Bound Isoform: Cell Membrane
Single-Pass Type I Membrane Protein
Does Not Seem To Be Active
Neuregulin-4: Secreted
Alternative CLIA Names Pro-Neuregulin-4 - Membrane-Bound Isoform CLIA kit
Pro-Nrg4 Cleaved Into - Neuregulin-4 CLIA kit
Nrg-4 CLIA kit
NRG4 CLIA kit
Specificity This kit recognizes Human NRG-4 in samples. No significant cross-reactivity or interference between Human NRG-4 and analogues was observed.
Reproducibility Both intra-CV and inter-CV are

Information sourced from Uniprot.org


Item Specifications Storage
Micro CLIA Plate (Dismountable) 96T: 8 wells ×12 strips strips -20℃, 6 months
Reference Standard 96T: 2 vials 48T: 1 vial -20℃, 6 months
Concentrated Biotinylated Detection Ab (100×) 96T: 1 vial, 120 μL 60 μL -20℃, 6 months
Concentrated HRP Conjugate (100×) 96T: 1 vial, 120 μL 60 μL -20℃ (Protect from light), 6 months
Reference Standard & Sample Diluent 1 vial, 20 mL 2-8°C, 6 months
Biotinylated Detection Ab Diluent 1 vial, 14 mL 2-8°C, 6 months
HRP Conjugate Diluent 1 vial, 14 mL 2-8°C, 6 months
Concentrated Wash Buffer (25×) 1 vial, 30 mL 2-8°C, 6 months
Substrate Reagent A 1 vial, 5 mL 2-8℃ (Protect from light)
Substrate Reagent B 1 vial, 5 mL 2-8℃ (Protect from light)
Plate Sealer 5 pieces
Manual 1 copy
Certificate of Analysis 1 copy

Sample Type Range (%) Average Recovery (%)
Serum(n=8) 96-110 103
EDTA plasma(n=8) 95-110 102
Cell culture media(n=8) 93-108 100

Intra-assay Precision Intra-assay Precision Intra-assay Precision Inter-assay Precision Inter-assay Precision Inter-assay Precision
Sample 1.00 2.00 3.00 1.00 2.00 3.00
n 20.00 20.00 20.00 20.00 20.00 20.00
Mean (ng/mL) 0.50 1.13 4.73 0.52 1.21 4.79
Standard deviation 0.06 0.12 0.36 0.06 0.10 0.34
CV (%) 12.00 10.62 7.61 11.54 8.26 7.10
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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