产品详情

  • 产品名称：Anti-BIRC3 antibody (109-118) (STJ72373)

  • 产品型号：STJ72373-100
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-BIRC3 antibody (109-118) (STJ72373)
详情介绍：
Host: Goat
Applications: Pep-ELISA/WB/IHC
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Goat polyclonal antibody anti-BIRC3 (109-118) is suitable for use in ELISA, Western Blot and Immunohistochemistry research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA
Purification: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration: 0.5 mg/mL
Dilution Range: WB-0.1-0.3µg/ml
IHC-5µg/ml
ELISA-antibody detection limit dilution 1:32000.
Storage Instruction: Store at-20°C on receipt and minimise freeze-thaw cycles.
Gene Symbol: BIRC3
Gene ID: 330
Uniprot ID: BIRC3_HUMAN
Immunogen Region: 109-118
Accession Number: NP_001156.1
Specificity: Reported variants represent identical protein: NP_892007.1, NP_001156.1
Immunogen Sequence: SQPTFPSSVT
Post Translational Modifications Auto-ubiquitinated and degraded by the proteasome in apoptotic cells.
Function Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates both canonical and non-canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins for its E3 ubiquitin-protein ligase activity include: RIPK1, RIPK2, RIPK3, RIPK4, CASP3, CASP7, CASP8, IKBKE, TRAF1, and BCL10. Acts as an important regulator of innate immune signaling via regulation of Toll-like receptors (TLRs), Nodlike receptors (NLRs) and RIG-I like receptors (RLRs), collectively referred to as pattern recognition receptors (PRRs). Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase-independent manner. Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8.
Protein Name Baculoviral Iap Repeat-Containing Protein 3
Apoptosis Inhibitor 2
Api2
Cellular Inhibitor Of Apoptosis 2
C-Iap2
Iap Homolog C
Inhibitor Of Apoptosis Protein 1
Hiap-1
Hiap1
Ring Finger Protein 49
Ring-Type E3 Ubiquitin Transferase Birc3
Tnfr2-Traf-Signaling Complex Protein 1
Database Links Reactome: R-HSA-168638
Reactome: R-HSA-168927
Reactome: R-HSA-5213460
Reactome: R-HSA-5357786
Reactome: R-HSA-5357905
Reactome: R-HSA-5357956
Reactome: R-HSA-5668541
Reactome: R-HSA-5675482
Reactome: R-HSA-5676594
Reactome: R-HSA-5689880
Reactome: R-HSA-937041
Cellular Localisation Cytoplasm
Nucleus
Alternative Antibody Names Anti-Baculoviral Iap Repeat-Containing Protein 3 antibody
Anti-Apoptosis Inhibitor 2 antibody
Anti-Api2 antibody
Anti-Cellular Inhibitor Of Apoptosis 2 antibody
Anti-C-Iap2 antibody
Anti-Iap Homolog C antibody
Anti-Inhibitor Of Apoptosis Protein 1 antibody
Anti-Hiap-1 antibody
Anti-Hiap1 antibody
Anti-Ring Finger Protein 49 antibody
Anti-Ring-Type E3 Ubiquitin Transferase Birc3 antibody
Anti-Tnfr2-Traf-Signaling Complex Protein 1 antibody
Anti-BIRC3 antibody
Anti-API2 antibody
Anti-MIHC antibody
Anti-RNF49 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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