产品详情

  • 产品名称：Human SCF (Stem Cell Factor) Sandwich ELISA Kit (STJE0007230)

  • 产品型号：STJE0007230
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Human SCF (Stem Cell Factor) Sandwich ELISA Kit (STJE0007230)
详情介绍：
Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 12.2pg/mL
Detection Limit: 31.2-2000pg/mL
Short Description: This SCF Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 4.5 hrs
Gene Symbol: KITLG
Gene ID: 4254
Uniprot ID: SCF_HUMAN
Sample Type: serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.
Tissue Specificity
Post Translational Modifications A soluble form (sKITLG) is produced by proteolytic processing of isoform 1 in the extracellular domain. Found in two differentially glycosylated forms, LMW-SCF and HMW-SCF. LMW-SCF is fully N-glycosylated at Asn-145, partially N-glycosylated at Asn-90, O-glycosylated at Ser-167, Thr-168 and Thr-180, and not glycosylated at Asn-97 or Asn-118. HMW-SCF is N-glycosylated at Asn-118, Asn-90 and Asn-145, O-glycosylated at Ser-167, Thr-168 and Thr-180, and not glycosylated at Asn-97. A soluble form exists as a cleavage product of the extracellular domain.
Function Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. KITLG/SCF and KIT also transmit signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. KITLG/SCF and KIT promote activation of STAT family members STAT1, STAT3 and STAT5. KITLG/SCF and KIT promote activation of PLCG1, leading to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. KITLG/SCF acts synergistically with other cytokines, probably interleukins.
Protein Name Kit Ligand
Mast Cell Growth Factor
Mgf
Stem Cell Factor
Scf
C-Kit Ligand Cleaved Into - Soluble Kit Ligand
Skitlg
Database Links Reactome: R-HSA-1257604 P21583-1
Reactome: R-HSA-1433557 P21583-1
Reactome: R-HSA-1433559 P21583-1
Reactome: R-HSA-2219530 P21583-1
Reactome: R-HSA-5673001 P21583-1
Reactome: R-HSA-6811558 P21583-1
Cellular Localisation Isoform 1: Cell Membrane
Single-Pass Type I Membrane Protein
Isoform 2: Cytoplasm
Cytoplasm
Cytoskeleton
Cell Membrane
Cell Projection
Lamellipodsium
Filopodium
Soluble Kit Ligand: Secreted
Alternative ELISA Names Kit Ligand ELISA kit
Mast Cell Growth Factor ELISA kit
Mgf ELISA kit
Stem Cell Factor ELISA kit
Scf ELISA kit
C-Kit Ligand Cleaved Into - Soluble Kit Ligand ELISA kit
Skitlg ELISA kit
KITLG ELISA kit
MGF ELISA kit
SCF ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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