产品详情

  • 产品名称：Anti-Cleaved-NOTCH2-A1734 antibody (1715-1764 aa) (STJ90067)

  • 产品型号：STJ90067
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-Cleaved-NOTCH2-A1734 antibody (1715-1764 aa) (STJ90067)
详情介绍：
Host: Rabbit
Applications: WB/ELISA
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Cleaved-Neurogenic locus notch homolog protein 2-A1734 (1715-1764 aa) is suitable for use in Western Blot and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-1:2000
ELISA 1:10000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: NOTCH2
Gene ID: 4853
Uniprot ID: NOTC2_HUMAN
Immunogen Region: 1715-1764 aa
Specificity: Cleaved-Notch 2 (A1734) Polyclonal Antibody detects endogenous levels of fragment of activated Notch 2 protein resulting from cleavage adjacent to A1734.
Immunogen: The antiserum was produced against synthesized peptide derived from the human NOTCH2 at the amino acid range 1715-1764
Post Translational Modifications Synthesized in the endoplasmic reticulum as an inactive form which is proteolytically cleaved by a furin-like convertase in the trans-Golgi network before it reaches the plasma membrane to yield an active, ligand-accessible form. Cleavage results in a C-terminal fragment N(TM) and a N-terminal fragment N(EC). Following ligand binding, it is cleaved by TNF-alpha converting enzyme (TACE) to yield a membrane-associated intermediate fragment called notch extracellular truncation (NEXT). This fragment is then cleaved by presenilin dependent gamma-secretase to release a notch-derived peptide containing the intracellular domain (NICD) from the membrane. Hydroxylated by HIF1AN. Can be either O-glucosylated or O-xylosylated at Ser-613 by POGLUT1. Phosphorylated by GSK3. GSK3-mediated phosphorylation is necessary for NOTCH2 recognition by FBXW7, ubiquitination and degradation via the ubiquitin proteasome pathway.
Function Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in bone remodeling and homeostasis. In collaboration with RELA/p65 enhances NFATc1 promoter activity and positively regulates RANKL-induced osteoclast differentiation. Positively regulates self-renewal of liver cancer cells.
Protein Name Neurogenic Locus Notch Homolog Protein 2
Notch 2
Hn2 Cleaved Into - Notch 2 Extracellular Truncation
N2ecd - Notch 2 Intracellular Domain
N2icd
Database Links Reactome: R-HSA-1912399
Reactome: R-HSA-1912408
Reactome: R-HSA-1912420
Reactome: R-HSA-2197563
Reactome: R-HSA-2979096
Reactome: R-HSA-350054
Reactome: R-HSA-5083630
Reactome: R-HSA-9013695
Cellular Localisation Notch 2 Extracellular Truncation: Cell Membrane
Single-Pass Type I Membrane Protein
Notch 2 Intracellular Domain: Nucleus
Cytoplasm
Following Proteolytical Processing Nicd Is Translocated To The Nucleus
Retained At The Cytoplasm By Tcim
Alternative Antibody Names Anti-Neurogenic Locus Notch Homolog Protein 2 antibody
Anti-Notch 2 antibody
Anti-Hn2 Cleaved Into - Notch 2 Extracellular Truncation antibody
Anti-N2ecd - Notch 2 Intracellular Domain antibody
Anti-N2icd antibody
Anti-NOTCH2 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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