产品详情

  • 产品名称：Human UBE3A (Ubiquitin Protein Ligase E3A) Sandwich ELISA Kit Ready-To-Use (STJE0019285)

  • 产品型号：STJE0019285
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Human UBE3A (Ubiquitin Protein Ligase E3A) Sandwich ELISA Kit Ready-To-Use (STJE0019285)
详情介绍：
Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.102ng/mL
Detection Limit: 0.312-20ng/mL
Short Description: This UBE3A Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 3 hrs
Gene Symbol: UBE3A
Gene ID: 7337
Uniprot ID: UBE3A_HUMAN
Immunogen Region: Ready-To-Use
Sample Type: serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.
Tissue Specificity
Post Translational Modifications Phosphorylation at Tyr-659 by ABL1 impairs E3 ligase activity and protects p53/TP53 from degradation in (HPV)-infected cells.
Function E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates. Several substrates have been identified including the BMAL1, ARC, LAMTOR1, RAD23A and RAD23B, MCM7 (which is involved in DNA replication), annexin A1, the PML tumor suppressor, and the cell cycle regulator CDKN1B. Additionally, may function as a cellular quality control ubiquitin ligase by helping the degradation of the cytoplasmic misfolded proteins. Finally, UBE3A also promotes its own degradation in vivo. Plays an important role in the regulation of the circadian clock: involved in the ubiquitination of the core clock component BMAL1, leading to its proteasomal degradation. Acts as transcriptional coactivator of progesterone receptor PGR upon progesterone hormone activation. Acts as a regulator of synaptic development by mediating ubiquitination and degradation of ARC. Required for synaptic remodeling in neurons by mediating ubiquitination and degradation of LAMTOR1, thereby limiting mTORC1 signaling and activity-dependent synaptic remodeling. Synergizes with WBP2 in enhancing PGR activity. (Microbial infection) Catalyzes the high-risk human papilloma virus E6-mediated ubiquitination of p53/TP53, contributing to the neoplastic progression of cells infected by these viruses.
Protein Name Ubiquitin-Protein Ligase E3a
E6ap Ubiquitin-Protein Ligase
Hect-Type Ubiquitin Transferase E3a
Human Papillomavirus E6-Associated Protein
Oncogenic Protein-Associated Protein E6-Ap
Renal Carcinoma Antigen Ny-Ren-54
Database Links Reactome: R-HSA-983168
Cellular Localisation Cytoplasm
Nucleus
Alternative ELISA Names Ubiquitin-Protein Ligase E3a ELISA kit
E6ap Ubiquitin-Protein Ligase ELISA kit
Hect-Type Ubiquitin Transferase E3a ELISA kit
Human Papillomavirus E6-Associated Protein ELISA kit
Oncogenic Protein-Associated Protein E6-Ap ELISA kit
Renal Carcinoma Antigen Ny-Ren-54 ELISA kit
UBE3A ELISA kit
E6AP ELISA kit
EPVE6AP ELISA kit
HPVE6A ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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