产品详情

  • 产品名称：Anti-Cd14 antibody [Sa14-2] {AF488} (STJA0001969)

  • 产品型号：STJA0001969
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-Cd14 antibody [Sa14-2] {AF488} (STJA0001969)
详情介绍：
Host: Rat
Applications: FC
Reactivity: Mouse
Note: FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS.
Short Description: Rat monoclonal antibody anti-Monocyte differentiation antigen CD14 is suitable for use in Flow Cytometry research applications.
Clonality: Monoclonal
Clone ID: Sa14-2
Conjugation: AF488
Isotype: IgG2ak
Formulation: PBS with 0.05% Proclin300, 1% BSA
Storage Instruction: Recommend storing between 2-8°C and protecting from prolonged exposure to light. Do not freeze this product.
Gene Symbol: Cd14
Gene ID: 12475
Uniprot ID: CD14_MOUSE
Tissue Specificity Detected on peritoneal macrophages (at protein level). Cell surface expression detected in lung alveolar macrophages, dendritic macrophages and lung macrophages (at protein level).
Function Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell surface and subsequently are targeted to the Golgi in a lipid-raft dependent pathway. Acts as an accessory receptor for M.tuberculosis lipoproteins LprA, LprG and LpqH, in conjunction with coreceptors TLR2 and TLR1. The lipoproteins act as agonists to modulate antigen presenting cell functions in response to the pathogen. Binds electronegative LDL (LDL(-)) and mediates the cytokine release induced by LDL(-).
Protein Name Monocyte Differentiation Antigen Cd14
Myeloid Cell-Specific Leucine-Rich Glycoprotein
Cd Antigen Cd14
Database Links Reactome: R-MMU-140534
Reactome: -MMU-166016
Reactome: -MMU-166020
Reactome: -MMU-166166
Reactome: -MMU-2562578
Reactome: -MMU-5686938
Reactome: -MMU-6798695
Reactome: -MMU-936964
Reactome: -MMU-937041
Reactome: -MMU-937072
Reactome: -MMU-975163
Cellular Localisation Cell Membrane
Lipid-Anchor
Gpi-Anchor
Secreted
Membrane Raft
Golgi Apparatus
Soluble
Secreted Forms Seem To Exist
They May Arise By Cleavage Of The Gpi Anchor
Alternative Antibody Names Anti-Monocyte Differentiation Antigen Cd14 antibody
Anti-Myeloid Cell-Specific Leucine-Rich Glycoprotein antibody
Anti-Cd Antigen Cd14 antibody
Anti-Cd14 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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