产品详情

  • 产品名称：Anti-CXCR3 antibody (200-300) [S0MR] (STJ11101310)

  • 产品型号：STJ11101310
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-CXCR3 antibody (200-300) [S0MR] (STJ11101310)
详情介绍：
Host: Rabbit
Applications: WB/IF
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit monoclonal antibody anti-CXCR3 (200-300) is suitable for use in Western Blot and Immunofluorescence research applications.
Clonality: Monoclonal
Clone ID: S0MR
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
IF/ICC 1:50-1:200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: CXCR3
Gene ID: 2833
Uniprot ID: CXCR3_HUMAN
Immunogen Region: 200-300
Immunogen: A synthetic peptide corresponding to a sequence within amino acids 200-300 of human CXCR3 (P49682).
Immunogen Sequence: ATHCQYNFPQVGRTALRVLQ LVAGFLLPLLVMAYCYAHIL AVLLVSRGQRRLRAMRLVVV VVVAFALCWTPYHLVVLVDI LMDLGALARNCGRESRVDVA K
Tissue Specificity Isoform 1 and isoform 2 are mainly expressed in heart, kidney, liver and skeletal muscle. Isoform 1 is also expressed in placenta. Isoform 2 is expressed in endothelial cells. Expressed in T-cells (at protein level).
Post Translational Modifications Sulfation on Tyr-27 and Tyr-29 is essential for CXCL10 binding and subsequent signal transduction induction. N-glycosylated.
Function Isoform 1: Receptor for the C-X-C chemokine CXCL9, CXCL10 and CXCL11 and mediates the proliferation, survival and angiogenic activity of human mesangial cells (HMC) through a heterotrimeric G-protein signaling pathway. Binds to CCL21. Probably promotes cell chemotaxis response. Isoform 2: Receptor for the C-X-C chemokine CXCL4 and also mediates the inhibitory activities of CXCL9, CXCL10 and CXCL11 on the proliferation, survival and angiogenic activity of human microvascular endothelial cells (HMVEC) through a cAMP-mediated signaling pathway. Does not promote cell chemotaxis respons. Interaction with CXCL4 or CXCL10 leads to activation of the p38MAPK pathway and contributes to inhibition of angiogenesis. Overexpression in renal cancer cells down-regulates expression of the anti-apoptotic protein HMOX1 and promotes apoptosis. Isoform 3: Mediates the activity of CXCL11.
Protein Name C-X-C Chemokine Receptor Type 3
Cxc-R3
Cxcr-3
Ckr-L2
G Protein-Coupled Receptor 9
Interferon-Inducible Protein 10 Receptor
Ip-10 Receptor
Cd Antigen Cd183
Database Links Reactome: R-HSA-380108
Reactome: R-HSA-418594
Cellular Localisation Isoform 1: Cell Membrane
Multi-Pass Membrane Protein
Isoform 2: Cell Membrane
Alternative Antibody Names Anti-C-X-C Chemokine Receptor Type 3 antibody
Anti-Cxc-R3 antibody
Anti-Cxcr-3 antibody
Anti-Ckr-L2 antibody
Anti-G Protein-Coupled Receptor 9 antibody
Anti-Interferon-Inducible Protein 10 Receptor antibody
Anti-Ip-10 Receptor antibody
Anti-Cd Antigen Cd183 antibody
Anti-CXCR3 antibody
Anti-GPR9 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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