产品详情

  • 产品名称：Anti-DEFA1/DEFA1B antibody (3-52 aa) (STJ92687)

  • 产品型号：STJ92687
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-DEFA1/DEFA1B antibody (3-52 aa) (STJ92687)
详情介绍：
Host: Rabbit
Applications: IHC/IF/ELISA
Reactivity: Human/Rat/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Neutrophil defensin 1 (3-52 aa) is suitable for use in Immunohistochemistry, Immunofluorescence and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: IHC 1:100-1:300
ELISA 1:40000
IF 1:50-200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: DEFA1.DEFA1B
Gene ID: 1667/728358
Uniprot ID: DEF1_HUMAN
Immunogen Region: 3-52 aa
Specificity: Defensin Alpha 1 Polyclonal Antibody detects endogenous levels of Defensin Alpha 1 protein.
Immunogen: The antiserum was produced against synthesized peptide derived from the human Defensin alpha1 at the amino acid range 3-52
Function Effector molecule of the innate immune system that acts via antibiotic-like properties against a broad array of infectious agents including bacteria, fungi, and viruses or by promoting the activation and maturation of some APCs. Interacts with the essential precursor of cell wall synthesis lipid II to inhibit bacterial cell wall synthesis. Inhibits adenovirus infection via inhibition of viral disassembly at the vertex region, thereby restricting the release of internal capsid protein pVI, which is required for endosomal membrane penetration during cell entry. In addition, interaction with adenovirus capsid leads to the redirection of viral particles to TLR4 thereby promoting a NLRP3-mediated inflammasome response and interleukin 1-beta (IL-1beta) release. Induces the production of proinflammatory cytokines including type I interferon (IFN) in plasmacytoid dendritic cells (pDCs) by triggering the degradation of NFKBIA and nuclear translocations of IRF1, both of which are required for activation of pDCs.
Protein Name Neutrophil Defensin 1
Defensin - Alpha 1
Hnp-1
Hp-1
Hp1 Cleaved Into - Hp 1-56 - Neutrophil Defensin 2
Hnp-2
Hp-2
Hp2
Database Links Reactome: R-HSA-1461973
Reactome: R-HSA-1462054
Reactome: R-HSA-6798695
Cellular Localisation Secreted
Alternative Antibody Names Anti-Neutrophil Defensin 1 antibody
Anti-Defensin - Alpha 1 antibody
Anti-Hnp-1 antibody
Anti-Hp-1 antibody
Anti-Hp1 Cleaved Into - Hp 1-56 - Neutrophil Defensin 2 antibody
Anti-Hnp-2 antibody
Anti-Hp-2 antibody
Anti-Hp2 antibody
Anti-DEFA1 antibody
Anti-DEF1 antibody
Anti-DEFA2 antibody
Anti-MRS.DEFA1B antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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