产品详情

  • 产品名称：Anti-DOK2 antibody (1-260) (STJ116019)

  • 产品型号：STJ116019
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-DOK2 antibody (1-260) (STJ116019)
详情介绍：
Host: Rabbit
Applications: WB
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-DOK2 (1-260) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: DOK2
Gene ID: 9046
Uniprot ID: DOK2_HUMAN
Immunogen Region: 1-260
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human DOK2 (NP_003965.2).
Immunogen Sequence: MGDGAVKQGFLYLQQQQTFG KKWRRFGASLYGGSDCALAR LELQEGPEKPRRCEAARKVI RLSDCLRVAEAGGEASSPRD TSAFFLETKERLYLLAAPAA ERGDWVQAICLLAFPGQRKE LSGPEGKQSRPCMEENELYS SAVTVGPHKEFAVTMRPTEA SERCHLRGSYTLRAGESALE LWGGPEPGTQLYDWPYRFLR RFGRDKVTFSFEAGRRCVSG EGNFEFETRQGNEIFLALE
Tissue Specificity Highly expressed in peripheral blood leukocytes, lymph nodes and spleen. Lower expression in thymus, bone marrow and fetal liver.
Post Translational Modifications On immunoreceptor stimulation, phosphorylated on C-terminal tyrosine residues. Phosphorylation on Tyr-345 is required for binding to the SH2 domain of NCK. Phosphorylation on both Tyr-271 and Tyr-299 is required for interaction with RASGAP. Phosphorylated on tyrosine residues by TEK/TIE2.
Function DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK2 may modulate the cellular proliferation induced by IL-4, as well as IL-2 and IL-3. May be involved in modulating Bcr-Abl signaling. Attenuates EGF-stimulated MAP kinase activation.
Protein Name Docking Protein 2
Downstream Of Tyrosine Kinase 2
P56(Dok-2
Database Links Reactome: R-HSA-210993
Reactome: R-HSA-8853659
Alternative Antibody Names Anti-Docking Protein 2 antibody
Anti-Downstream Of Tyrosine Kinase 2 antibody
Anti-P56(Dok-2 antibody
Anti-DOK2 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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