产品详情

  • 产品名称：Anti-EFNB2 antibody (28-229) (STJ114827)

  • 产品型号：STJ114827
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-EFNB2 antibody (28-229) (STJ114827)
详情介绍：
Host: Rabbit
Applications: WB
Reactivity: Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-EFNB2 (28-229) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: EFNB2
Gene ID: 1948
Uniprot ID: EFNB2_HUMAN
Immunogen Region: 28-229
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 28-229 of human Ephrin B2 (NP_004084.1).
Immunogen Sequence: IVLEPIYWNSSNSKFLPGQG LVLYPQIGDKLDIICPKVDS KTVGQYEYYKVYMVDKDQAD RCTIKKENTPLLNCAKPDQD IKFTIKFQEFSPNLWGLEFQ KNKDYYIISTSNGSLEGLDN QEGGVCQTRAMKILMKVGQD ASSAGSTRNKDPTRRPELEA GTNGRSSTTSPFVKPNPGSS TDGNSAGHSGNNILGSevals FA
Tissue Specificity Lung and kidney.
Post Translational Modifications Inducible phosphorylation of tyrosine residues in the cytoplasmic domain.
Function Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds to receptor tyrosine kinase including EPHA4, EPHA3 and EPHB4. Together with EPHB4 plays a central role in heart morphogenesis and angiogenesis through regulation of cell adhesion and cell migration. EPHB4-mediated forward signaling controls cellular repulsion and segregation from EFNB2-expressing cells. May play a role in constraining the orientation of longitudinally projecting axons. (Microbial infection) Acts as a receptor for Hendra virus and Nipah virus.
Protein Name Ephrin-B2
Eph-Related Receptor Tyrosine Kinase Ligand 5
Lerk-5
Htk Ligand
Htk-L
Database Links Reactome: R-HSA-2682334
Reactome: R-HSA-3928662
Reactome: R-HSA-3928664
Reactome: R-HSA-3928665
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Cell Junction
Adherens Junction
Alternative Antibody Names Anti-Ephrin-B2 antibody
Anti-Eph-Related Receptor Tyrosine Kinase Ligand 5 antibody
Anti-Lerk-5 antibody
Anti-Htk Ligand antibody
Anti-Htk-L antibody
Anti-EFNB2 antibody
Anti-EPLG5 antibody
Anti-HTKL antibody
Anti-LERK5 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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