产品详情

  • 产品名称：Anti-EIF3B antibody (STJA0007421)

  • 产品型号：STJA0007421
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-EIF3B antibody (STJA0007421)
详情介绍：
Host: Rabbit
Applications: WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Eukaryotic translation initiation factor 3 subunit B is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: EIF3B
Gene ID: 8662
Uniprot ID: EIF3B_HUMAN
Specificity: This antibody detects endogenous levels of EIF3B at Human, Mouse, Rat
Immunogen: Synthesized peptide derived from human EIF3B
Function RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. (Microbial infection) In case of FCV infection, plays a role in the ribosomal termination-reinitiation event leading to the translation of VP2.
Protein Name Eukaryotic Translation Initiation Factor 3 Subunit B
Eif3b
Eukaryotic Translation Initiation Factor 3 Subunit 9
Prt1 Homolog
Hprt1
Eif-3-Eta
Eif3 P110
Eif3 P116
Database Links Reactome: R-HSA-156827
Reactome: R-HSA-72649
Reactome: R-HSA-72689
Reactome: R-HSA-72695
Reactome: R-HSA-72702
Reactome: R-HSA-72706
Cellular Localisation Cytoplasm
Stress Granule
Localizes To Stress Granules Following Cellular Stress
Alternative Antibody Names Anti-Eukaryotic Translation Initiation Factor 3 Subunit B antibody
Anti-Eif3b antibody
Anti-Eukaryotic Translation Initiation Factor 3 Subunit 9 antibody
Anti-Prt1 Homolog antibody
Anti-Hprt1 antibody
Anti-Eif-3-Eta antibody
Anti-Eif3 P110 antibody
Anti-Eif3 P116 antibody
Anti-EIF3B antibody
Anti-EIF3S9 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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