产品详情

  • 产品名称：Anti-EPHB4 antibody (900-984) (STJ500939)

  • 产品型号：STJ500939-100
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-EPHB4 antibody (900-984) (STJ500939)
详情介绍：
Host: Rabbit
Applications: ELISA/IP/WB
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-EPHB4 (900-984) is suitable for use in ELISA, Immunoprecipitation and Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Purification: Affinity Purified
Concentration: 0.55-0.62 µg/µl
Dilution Range: WB: 1:500
DB: 1:10, 000
ELISA: 1:10, 000
IP: 1:200
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: EPHB4
Gene ID: 2050
Uniprot ID: EPHB4_HUMAN
Immunogen Region: 900-984
Immunogen: Synthetic peptide taken within amino acid region 900-984 on human Ephrin B4 receptor protein.
Tissue Specificity Abundantly expressed in placenta but also detected in kidney, liver, lung, pancreas, skeletal muscle and heart. Expressed in primitive and myeloid, but not lymphoid, hematopoietic cells. Also observed in cell lines derived from liver, breast, colon, lung, melanocyte and cervix.
Post Translational Modifications Phosphorylated.autophosphorylation is stimulated by EFNB2.
Function Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Together with its cognate ligand/functional ligand EFNB2 it is involved in the regulation of cell adhesion and migration, and plays a central role in heart morphogenesis, angiogenesis and blood vessel remodeling and permeability. EPHB4-mediated forward signaling controls cellular repulsion and segregation from EFNB2-expressing cells.
Protein Name Ephrin Type-B Receptor 4
Hepatoma Transmembrane Kinase
Tyrosine-Protein Kinase Tyro11
Database Links Reactome: R-HSA-2682334
Reactome: R-HSA-3928662
Reactome: R-HSA-3928664
Reactome: R-HSA-3928665
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Alternative Antibody Names Anti-Ephrin Type-B Receptor 4 antibody
Anti-Hepatoma Transmembrane Kinase antibody
Anti-Tyrosine-Protein Kinase Tyro11 antibody
Anti-EPHB4 antibody
Anti-HTK antibody
Anti-MYK1 antibody
Anti-TYRO11 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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