产品详情

  • 产品名称：Anti-EPHB4 antibody [5B8F7] (STJ98034)

  • 产品型号：STJ98034
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-EPHB4 antibody [5B8F7] (STJ98034)
详情介绍：
Host: Mouse
Applications: WB/IHC/IF/ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Mouse monoclonal antibody anti-Ephrin type-B receptor 4 is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications.
Clonality: Monoclonal
Clone ID: 5B8F7
Conjugation: Unconjugated
Isotype: IgG2a
Formulation: Liquid in PBS containing 0.03% Sodium Azide, 0.5% BSA, 50% Glycerol.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
IHC 1:200-1:1000
ELISA 1:10000
IF 1:50-200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: EPHB4
Gene ID: 2050
Uniprot ID: EPHB4_HUMAN
Specificity: EphB4 Monoclonal Antibody detects endogenous levels of EphB4 protein.
Immunogen: Purified recombinant fragment of EphB4 expressed in E. Coli.
Post Translational Modifications Phosphorylated.autophosphorylation is stimulated by EFNB2.
Function Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Together with its cognate ligand/functional ligand EFNB2 it is involved in the regulation of cell adhesion and migration, and plays a central role in heart morphogenesis, angiogenesis and blood vessel remodeling and permeability. EPHB4-mediated forward signaling controls cellular repulsion and segregation from EFNB2-expressing cells.
Protein Name Ephrin Type-B Receptor 4
Hepatoma Transmembrane Kinase
Tyrosine-Protein Kinase Tyro11
Database Links Reactome: R-HSA-2682334
Reactome: R-HSA-3928662
Reactome: R-HSA-3928664
Reactome: R-HSA-3928665
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Alternative Antibody Names Anti-Ephrin Type-B Receptor 4 antibody
Anti-Hepatoma Transmembrane Kinase antibody
Anti-Tyrosine-Protein Kinase Tyro11 antibody
Anti-EPHB4 antibody
Anti-HTK antibody
Anti-MYK1 antibody
Anti-TYRO11 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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