Anti-FBXW11 antibody (519-542) (STJ110094) STJ110094|產品目錄|代理商|上海91麻豆福利视频网生物科技有限公司

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產品名稱：Anti-FBXW11 antibody (519-542) (STJ110094)
產品型號：STJ110094
產品廠商：ST john's laboratory
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Anti-FBXW11 antibody (519-542) (STJ110094)

詳情介紹：

Host:	Rabbit
Applications:	WB/IF
Reactivity:	Human/Mouse/Rat
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-FBXW11 (519-542) is suitable for use in Western Blot and Immunofluorescence research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification:	Affinity purification
Dilution Range:	WB 1:500-1:1000 IF/ICC 1:50-1:200
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	FBXW11
Gene ID:	23291
Uniprot ID:	FBW1B_HUMAN
Immunogen Region:	519-542
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 519-542 of human FBXW11 (NP_036432.2).
Immunogen Sequence:	FLNVPPSAQNETRS

Function	Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins: the interaction with substrates requires the phosphorylation of the two serine residues in the substrates' destruction motif D-S-G-X(2,3,4)-S. SCF(FBXW11) mediates the ubiquitination of phosphorylated CTNNB1 and participates in Wnt signaling regulation. SCF(FBXW11) plays a key role in NF-kappa-B activation by mediating ubiquitination of phosphorylated NFKBIA, leading to its degradation by the proteasome, thereby allowing the associated NF-kappa-B complex to translocate into the nucleus and to activate transcription. The SCF(FBXW11) complex also regulates NF-kappa-B by mediating ubiquitination of phosphorylated NFKB1: specifically ubiquitinates the p105 form of NFKB1, leading to its degradation. SCF(FBXW11) mediates the ubiquitination of IFNAR1. SCF(FBXW11) mediates the ubiquitination of CEP68.this is required for centriole separation during mitosis. Involved in the oxidative stress-induced a ubiquitin-mediated decrease in RCAN1. Mediates the degradation of CDC25A induced by ionizing radiation in cells progressing through S phase and thus may function in the intra-S-phase checkpoint. Has an essential role in the control of the clock-dependent transcription via degradation of phosphorylated PER1 and phosphorylated PER2. SCF(FBXW11) mediates the ubiquitination of CYTH1, and probably CYTH2. SCF(FBXW11) acts as a regulator of mTORC1 signaling pathway by catalyzing ubiquitination and subsequent proteasomal degradation of phosphorylated DEPTOR, TFE3 and MITF. (Microbial infection) Target of human immunodeficiency virus type 1 (HIV-1) protein VPU to polyubiquitinate and deplete BST2 from cells and antagonize its antiviral action.
Protein Name	F-Box/Wd Repeat-Containing Protein 11 F-Box And Wd Repeats Protein Beta-Trcp2 F-Box/Wd Repeat-Containing Protein 1b Homologous To Slimb Protein Hos
Database Links	Reactome: R-HSA-1169091 Reactome: R-HSA-202424 Reactome: R-HSA-2565942 Reactome: R-HSA-2871837 Reactome: R-HSA-5607761 Reactome: R-HSA-5607764 Reactome: R-HSA-5676590 Reactome: R-HSA-5684264 Reactome: R-HSA-8951664 Reactome: R-HSA-983168
Cellular Localisation	Cytoplasm Nucleus
Alternative Antibody Names	Anti-F-Box/Wd Repeat-Containing Protein 11 antibody Anti-F-Box And Wd Repeats Protein Beta-Trcp2 antibody Anti-F-Box/Wd Repeat-Containing Protein 1b antibody Anti-Homologous To Slimb Protein antibody Anti-Hos antibody Anti-FBXW11 antibody Anti-BTRCP2 antibody Anti-FBW1B antibody Anti-FBXW1B antibody Anti-KIAA0696 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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產品名稱：Anti-FBXW11 antibody (519-542) (STJ110094)