Mouse EGLN1 (Egl Nine Homolog 1) Sandwich ELISA Kit Ready-To-Use (STJE0014982) STJE0014982|產品目錄|代理商|上海91麻豆福利视频网生物科技有限公司

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產品名稱：Mouse EGLN1 (Egl Nine Homolog 1) Sandwich ELISA Kit Ready-To-Use (STJE0014982)
產品型號：STJE0014982
產品廠商：ST john's laboratory
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Mouse EGLN1 (Egl Nine Homolog 1) Sandwich ELISA Kit Ready-To-Use (STJE0014982)

詳情介紹：

Applications:	ELISA
Reactivity:	Mouse
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity:	0.108ng/mL
Detection Limit:	0.312-20ng/mL
Short Description:	This EGLN1 Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in mouse cell culture supernatant, serum and plasma (EDTA, citrate, heparin).

Storage Instruction:	The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time:	3 hrs

Gene Symbol:	Egln1
Gene ID:	112405
Uniprot ID:	EGLN1_MOUSE
Immunogen Region:	Ready-To-Use
Sample Type:	tissue homogenates, cell lysates or other biological fluids.

Tissue Specificity	Expressed in heart, brain liver, skeletal muscle and kidney. Low levels were detected in the lung. Constitutively expressed during differentiation of C2C12 skeletal myocytes.
Post Translational Modifications	S-nitrosylation inhibits the enzyme activity up to 60% under aerobic conditions. Chelation of Fe(2+) has no effect on the S-nitrosylation. It is uncertain whether nitrosylation occurs on Cys-300 or Cys-303.
Function	Cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates a specific proline found in each of the oxygen-dependent degradation (ODD) domains (N-terminal, NODD, and C-terminal, CODD) of HIF1A. Also hydroxylates HIF2A. Has a preference for the CODD site for both HIF1A and HIF1B. Hydroxylated HIFs are then targeted for proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Under hypoxic conditions, the hydroxylation reaction is attenuated allowing HIFs to escape degradation resulting in their translocations to the nucleus, heterodimerization with HIF1B, and increased expression of hypoxy-inducible genes. EGLN1 is the most important isozyme under normoxia and, through regulating the stability of HIF1, involved in various hypoxia-influenced processes such as angiogenesis in retinal and cardiac functionality. Target proteins are preferentially recognized via a LXXLAP motif.
Protein Name	Egl Nine Homolog 1 Hypoxia-Inducible Factor Prolyl Hydroxylase 2 Hif-Ph2 Hif-Prolyl Hydroxylase 2 Hph-2 Prolyl Hydroxylase Domain-Containing Protein 2 Phd2 Sm-20
Database Links	Reactome: R-MMU-1234176
Cellular Localisation	Cytoplasm Nucleus Mainly Cytoplasmic Shuttles Between The Nucleus And Cytoplasm Nuclear Export Requires Functional Xpo1
Alternative ELISA Names	Egl Nine Homolog 1 ELISA kit Hypoxia-Inducible Factor Prolyl Hydroxylase 2 ELISA kit Hif-Ph2 ELISA kit Hif-Prolyl Hydroxylase 2 ELISA kit Hph-2 ELISA kit Prolyl Hydroxylase Domain-Containing Protein 2 ELISA kit Phd2 ELISA kit Sm-20 ELISA kit Egln1 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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產品名稱：Mouse EGLN1 (Egl Nine Homolog 1) Sandwich ELISA Kit Ready-To-Use (STJE0014982)