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Anti-DDRGK1 antibody (STJA0006843) STJA0006843|產品目錄|代理商|上海91麻豆福利视频网生物科技有限公司
產品詳情

  • 產品名稱：Anti-DDRGK1 antibody (STJA0006843)

  • 產品型號：STJA0006843
  • 產品廠商：ST john's laboratory
  • 產品文檔：
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簡單介紹：
Anti-DDRGK1 antibody (STJA0006843)
詳情介紹：
Host: Rabbit
Applications: WB
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-DDRGK domain-containing protein 1 is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: DDRGK1
Gene ID: 65992
Uniprot ID: DDRGK_HUMAN
Specificity: This antibody detects endogenous levels of DDRGK1 at Human, Mouse
Immunogen: Synthesized peptide derived from human DDRGK1
Post Translational Modifications Ubiquitinated. Ubiquitination probably triggers proteasomal degradation and is negatively regulated by UFL1, the enzyme involved in the ufmylation of DDRGK1. Ufmylated.conjugated to ubiquitin-like protein UFM1, probably at Lys-267 by UFL1. The relevance of ufmylation is however unclear: as DDRGK1 acts as substrate adapters for ufmylation, it is uncertain whether ufmylation is a collatoral effect of ufmylation process or is required to regulate its activity.
Function Substrate adapter for ufmylation, the covalent attachment of the ubiquitin-like modifier UFM1 to substrate proteins, which plays a key role in reticulophagy (also called ER-phagy). In response to endoplasmic reticulum stress, promotes recruitment of the E3 UFM1-protein ligase UFL1 to the endoplasmic reticulum membrane: in turn, UFL1 mediates ufmylation of proteins such as RPN1 and RPL26/uL24, promoting reticulophagy of endoplasmic reticulum sheets. Ufmylation-dependent reticulophagy inhibits the unfolded protein response (UPR) by regulating ERN1/IRE1-alpha stability. Ufmylation in response to endoplasmic reticulum stress is essential for processes such as hematopoiesis or inflammatory response. Required for TRIP4 ufmylation, thereby regulating nuclear receptors-mediated. transcription. May play a role in NF-kappa-B-mediated transcription through regulation of the phosphorylation and the degradation of NFKBIA, the inhibitor of NF-kappa-B. Plays a role in cartilage development through SOX9, inhibiting the ubiquitin-mediated proteasomal degradation of this transcriptional regulator.
Protein Name Ddrgk Domain-Containing Protein 1
Dashurin
Ufm1-Binding And Pci Domain-Containing Protein 1
Database Links Reactome: R-HSA-8980692
Cellular Localisation Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Localizes To The Endoplasmic Reticulum Membrane In Response To Endoplasmic Reticulum Stress
Alternative Antibody Names Anti-Ddrgk Domain-Containing Protein 1 antibody
Anti-Dashurin antibody
Anti-Ufm1-Binding And Pci Domain-Containing Protein 1 antibody
Anti-DDRGK1 antibody
Anti-C20orf116 antibody
Anti-UFBP1 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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