Anti-DIABLO antibody (56-239) (STJ23380) STJ23380|產品目錄|代理商|上海91麻豆福利视频网生物科技有限公司

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產品名稱：Anti-DIABLO antibody (56-239) (STJ23380)
產品型號：STJ23380
產品廠商：ST john's laboratory
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簡單介紹：

Anti-DIABLO antibody (56-239) (STJ23380)

詳情介紹：

Host:	Rabbit
Applications:	WB/IHC/IP
Reactivity:	Human/Mouse/Rat
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-DIABLO (56-239) is suitable for use in Western Blot, Immunohistochemistry and Immunoprecipitation research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification:	Affinity purification
Dilution Range:	WB 1:500-1:2000 IHC-P 1:50-1:200 IP 1:50-1:200
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	DIABLO
Gene ID:	56616
Uniprot ID:	DBLOH_HUMAN
Immunogen Region:	56-239
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 56-239 of human Smac/Diablo (NP_063940.1).
Immunogen Sequence:	AVPIAQKSEPHSLSSEALMR RAVSLVTDSTSTFLSQTTYA LIEAITEYTKAVYTLTSLYR QYTSLLGKMNSEEEDEVWQV IIGARAEMTSKHQEYLKLET TWMTAVGLSEMAAEAAYQTG ADQASITARNHIQLVKLQVE EVHQLSRKAETKLAEAQIEE LRQKTQEEGEERAESEQEAY LRED

Tissue Specificity	Ubiquitously expressed with highest expression in testis. Expression is also high in heart, liver, kidney, spleen, prostate and ovary. Low in brain, lung, thymus and peripheral blood leukocytes. Isoform 3 is ubiquitously expressed.
Post Translational Modifications	Ubiquitinated by BIRC7/livin. The precursor form is proteolytically cleaved by mitochondrial processing peptidase MPP to remove the transit peptide and produce an intermediate form. This is then processed by PARL to produce the mature cleaved form which is released from mitochondria into the cytosol in apoptotic cells.
Function	Promotes apoptosis by activating caspases in the cytochrome c/Apaf-1/caspase-9 pathway. Acts by opposing the inhibitory activity of inhibitor of apoptosis proteins (IAP). Inhibits the activity of BIRC6/bruce by inhibiting its binding to caspases. Isoform 3: Attenuates the stability and apoptosis-inhibiting activity of XIAP/BIRC4 by promoting XIAP/BIRC4 ubiquitination and degradation through the ubiquitin-proteasome pathway. Also disrupts XIAP/BIRC4 interacting with processed caspase-9 and promotes caspase-3 activation. Isoform 1: Defective in the capacity to down-regulate the XIAP/BIRC4 abundance.
Protein Name	Diablo Iap-Binding Mitochondrial Protein Diablo Homolog - Mitochondrial Direct Iap-Binding Protein With Low Pi Second Mitochondria-Derived Activator Of Caspase Smac Cleaved Into - Diablo Iap-Binding Mitochondrial Protein - Cleaved Form
Database Links	Reactome: R-HSA-111457 Reactome: R-HSA-111463 Reactome: R-HSA-111464 Reactome: R-HSA-111469 Reactome: R-HSA-9627069
Cellular Localisation	Mitochondrion Cytoplasm Cytosol Released Into The Cytosol In A Parl-Dependent Manner When Cells Undergo Apoptosis
Alternative Antibody Names	Anti-Diablo Iap-Binding Mitochondrial Protein antibody Anti-Diablo Homolog - Mitochondrial antibody Anti-Direct Iap-Binding Protein With Low Pi antibody Anti-Second Mitochondria-Derived Activator Of Caspase antibody Anti-Smac Cleaved Into - Diablo Iap-Binding Mitochondrial Protein - Cleaved Form antibody Anti-DIABLO antibody Anti-SMAC antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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產品名稱：Anti-DIABLO antibody (56-239) (STJ23380)