Anti-DIAPH1 antibody (1149-1263) (STJ28339) STJ28339|產品目錄|代理商|上海91麻豆福利视频网生物科技有限公司

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產品名稱：Anti-DIAPH1 antibody (1149-1263) (STJ28339)
產品型號：STJ28339
產品廠商：ST john's laboratory
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Anti-DIAPH1 antibody (1149-1263) (STJ28339)

詳情介紹：

Host:	Rabbit
Applications:	WB/IF
Reactivity:	Human/Mouse
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-DIAPH1 (1149-1263) is suitable for use in Western Blot and Immunofluorescence research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3.
Purification:	Affinity purification
Dilution Range:	WB 1:500-1:2000 IF/ICC 1:50-1:100
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	DIAPH1
Gene ID:	1729
Uniprot ID:	DIAP1_HUMAN
Immunogen Region:	1149-1263
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 1149-1263 of human DIAPH1 (NP_001073280.1).
Immunogen Sequence:	TEEKMRRAKLAKEKAEKERL EKQQKREQLIDMNAEGDETG VMDSLLEALQSGAAFRRKRG PRQANRKAGCAVTSLLASEL TKDDAMAAVPAKVSKNSETF PTILEEAKELVGRAS

Tissue Specificity	Expressed in brain, heart, placenta, lung, kidney, pancreas, liver, skeletal muscle and cochlea. Expressed in platelets.
Post Translational Modifications	Phosphorylation at Thr-768 is stimulated by cAMP and regulates stability, complex formation and mitochondrial movement.
Function	Actin nucleation and elongation factor required for the assembly of F-actin structures, such as actin cables and stress fibers. Binds to the barbed end of the actin filament and slows down actin polymerization and depolymerization. Required for cytokinesis, and transcriptional activation of the serum response factor. DFR proteins couple Rho and Src tyrosine kinase during signaling and the regulation of actin dynamics. Functions as a scaffold protein for MAPRE1 and APC to stabilize microtubules and promote cell migration. Has neurite outgrowth promoting activity. Acts in a Rho-dependent manner to recruit PFY1 to the membrane. In hear cells, it may play a role in the regulation of actin polymerization in hair cells. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape. Plays a role in brain development. Also acts as an actin nucleation and elongation factor in the nucleus by promoting nuclear actin polymerization inside the nucleus to drive serum-dependent SRF-MRTFA activity.
Protein Name	Protein Diaphanous Homolog 1 Diaphanous-Related Formin-1 Drf1
Database Links	Reactome: R-HSA-5663220 Reactome: R-HSA-6785631 Reactome: R-HSA-6798695 Reactome: R-HSA-8980692 Reactome: R-HSA-9013026 Reactome: R-HSA-9013106 Reactome: R-HSA-9013405 Reactome: R-HSA-9035034
Cellular Localisation	Cell Membrane Cell Projection Ruffle Membrane Cytoplasm Cytoskeleton Microtubule Organizing Center Centrosome Spindle Nucleus Membrane Ruffles Especially At The Tip Of Ruffles Of Motile Cells
Alternative Antibody Names	Anti-Protein Diaphanous Homolog 1 antibody Anti-Diaphanous-Related Formin-1 antibody Anti-Drf1 antibody Anti-DIAPH1 antibody Anti-DIAP1 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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產品名稱：Anti-DIAPH1 antibody (1149-1263) (STJ28339)