產品詳情
簡單介紹:
Anti-DLL4 antibody (27-524) (STJ11105504)
詳情介紹:
Host: | Rabbit |
Applications: | WB |
Reactivity: | Human |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description: | Rabbit polyclonal antibody anti-Delta-Like Protein 4 (27-524) is suitable for use in Western Blot research applications. |
Clonality: | Polyclonal |
Conjugation: | Unconjugated |
Isotype: | IgG |
Formulation: | PBS with 0.05% Proclin300, 50% Glycerol, pH7.3. |
Purification: | Affinity purification |
Dilution Range: | WB 1:500-1:1000 |
Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Gene Symbol: | DLL4 |
Gene ID: | 54567 |
Uniprot ID: | DLL4_HUMAN |
Immunogen Region: | 27-524 |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 27-524 of human DLL4 (NP_061947.1). |
Immunogen Sequence: | GVFQLQLQEFINERGVLASG RPCEPGCRTFFRVCLKHFQA VVSPGPCTFGTVSTPVLGTN SFAVRDDSSGGGRNPLQLPF NFTWPGTFSLIIEAWHAPGD DLRPEALPPDALISKIAIQG SLAVGQNWLLDEQTSTLTRL RYSYRVICSDNYYGDNCSRL CKKRNDHFGHYVCQPDGNLS CLPGWTGEYCQQPICLSGCH EQNGYCSKPAECLCRPGWQG RLCNECIPHNGCRHGTCST |
Tissue Specificity | Expressed in vascular endothelium. |
Function | Involved in the Notch signaling pathway as Notch ligand. Activates NOTCH1 and NOTCH4. Involved in angiogenesis.negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Essential for retinal progenitor proliferation. Required for suppressing rod fates in late retinal progenitors as well as for proper generation of other retinal cell types. During spinal cord neurogenesis, inhibits V2a interneuron fate. |
Protein Name | Delta-Like Protein 4 Drosophila Delta Homolog 4 Delta4 |
Database Links | Reactome: R-HSA-2122948 Reactome: R-HSA-2644606 Reactome: R-HSA-2660826 Reactome: R-HSA-2691232 Reactome: R-HSA-2894862 Reactome: R-HSA-2979096 Reactome: R-HSA-9013507 Reactome: R-HSA-9013700 |
Cellular Localisation | Cell Membrane Single-Pass Type I Membrane Protein |
Alternative Antibody Names | Anti-Delta-Like Protein 4 antibody Anti-Drosophila Delta Homolog 4 antibody Anti-Delta4 antibody Anti-DLL4 antibody Anti-UNQ1895 antibody Anti-PRO4341 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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