Anti-DNMT3L antibody (100-200) (STJ23417) STJ23417|產品目錄|代理商|上海91麻豆福利视频网生物科技有限公司

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產品名稱：Anti-DNMT3L antibody (100-200) (STJ23417)
產品型號：STJ23417
產品廠商：ST john's laboratory
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Anti-DNMT3L antibody (100-200) (STJ23417)

詳情介紹：

Host:	Rabbit
Applications:	WB/IHC
Reactivity:	Human/Mouse/Rat
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-DNMT3L (100-200) is suitable for use in Western Blot and Immunohistochemistry research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3.
Purification:	Affinity purification
Dilution Range:	WB 1:500-1:2000 IHC-P 1:50-1:200
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	DNMT3L
Gene ID:	29947
Uniprot ID:	DNM3L_HUMAN
Immunogen Region:	100-200
Immunogen:	A synthetic peptide corresponding to a sequence within amino acids 100-200 of human DNMT3L (NP_787063.1).
Immunogen Sequence:	CSGETLLICGNPDCTRCYCF ECVDSLVGPGTSGKVHAMSN WVCYLCLPSSRSGLLQRRRK WRSQLKAFYDRESENPLEMF ETVPVWRRQPVRVLSLFEDI K

Tissue Specificity	Expressed at low levels in several tissues including testis, ovary, and thymus.
Function	Catalytically inactive regulatory factor of DNA methyltransferases that can either promote or inhibit DNA methylation depending on the context. Essential for the function of DNMT3A and DNMT3B: activates DNMT3A and DNMT3B by binding to their catalytic domain. Acts by accelerating the binding of DNA and S-adenosyl-L-methionine (AdoMet) to the methyltransferases and dissociates from the complex after DNA binding to the methyltransferases. Recognizes unmethylated histone H3 lysine 4 (H3K4me0) and induces de novo DNA methylation by recruitment or activation of DNMT3. Plays a key role in embryonic stem cells and germ cells. In germ cells, required for the methylation of imprinted loci together with DNMT3A. In male germ cells, specifically required to methylate retrotransposons, preventing their mobilization. Plays a key role in embryonic stem cells (ESCs) by acting both as an positive and negative regulator of DNA methylation. While it promotes DNA methylation of housekeeping genes together with DNMT3A and DNMT3B, it also acts as an inhibitor of DNA methylation at the promoter of bivalent genes. Interacts with the EZH2 component of the PRC2/EED-EZH2 complex, preventing interaction of DNMT3A and DNMT3B with the PRC2/EED-EZH2 complex, leading to maintain low methylation levels at the promoters of bivalent genes. Promotes differentiation of ESCs into primordial germ cells by inhibiting DNA methylation at the promoter of RHOX5, thereby activating its expression.
Protein Name	Dna Cytosine-5-Methyltransferase 3-Like
Database Links	Reactome: R-HSA-5334118
Cellular Localisation	Nucleus
Alternative Antibody Names	Anti-Dna antibody Anti-Cytosine-5-Methyltransferase 3-Like antibody Anti-DNMT3L antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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產品名稱：Anti-DNMT3L antibody (100-200) (STJ23417)