產品詳情
簡單介紹：
Anti-DPYSL2 antibody (473-572) [S4MR] (STJ11102074)
詳情介紹：
| Host: | Rabbit |
| Applications: | WB/IF |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Rabbit monoclonal antibody anti-CRMP2 (473-572) is suitable for use in Western Blot and Immunofluorescence research applications. |
| Clonality: | Monoclonal |
| Clone ID: | S4MR |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH7.3. |
| Purification: | Affinity purification |
| Dilution Range: | WB 1:500-1:5000 IF/ICC 1:50-1:200 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | DPYSL2 |
| Gene ID: | 1808 |
| Uniprot ID: | DPYL2_HUMAN |
| Immunogen Region: | 473-572 |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 473-572 of human CRMP2/DPYSL2 (Q16555). |
| Immunogen Sequence: | PFPDFVYKRIKARSRLAELR GVPRGLYDGPVCEVSVTPKT VTPASSAKTSPAKQQAPPVR NLHQSGFSLSGAQIDDNIPR RTTQRIVAPPGGRANITSLG |
| Tissue Specificity | Ubiquitous. |
| Post Translational Modifications | 3F4, a monoclonal antibody which strongly stains neurofibrillary tangles in Alzheimer disease brains, specifically labels DPYSL2 when phosphorylated on Ser-518, Ser-522 and Thr-509. Phosphorylation at Thr-514 by GSK3B abolishes tubulin-binding leading to destabilization of microtubule assembly in axons and neurodegeneration. Phosphorylation by DYRK2 at Ser-522 is required for subsequent phosphorylation by GSK3B. |
| Function | Plays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal growth cone collapse and cell migration. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. May play a role in endocytosis. |
| Protein Name | Dihydropyrimidinase-Related Protein 2 Drp-2 Collapsin Response Mediator Protein 2 Crmp-2 N2a3 Unc-33-Like Phosphoprotein 2 Ulip-2 |
| Database Links | Reactome: R-HSA-399956 Reactome: R-HSA-437239 |
| Cellular Localisation | Cytoplasm Cytosol Cytoskeleton Membrane Tightly But Non-Covalently Associated With Membranes |
| Alternative Antibody Names | Anti-Dihydropyrimidinase-Related Protein 2 antibody Anti-Drp-2 antibody Anti-Collapsin Response Mediator Protein 2 antibody Anti-Crmp-2 antibody Anti-N2a3 antibody Anti-Unc-33-Like Phosphoprotein 2 antibody Anti-Ulip-2 antibody Anti-DPYSL2 antibody Anti-CRMP2 antibody Anti-ULIP2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
相關信息
![Anti-14-3-3 beta/Theta antibody (1-100) [S1MR] (STJ11103651)](http://y1.yzimgs.com/uploads/465546/2024520-20551366.png?imageView2/2/w/200/h/200)
- 細胞培養玄學-MRC-5細胞 2025-01-07
- Ocean NanoTech定製的詳細步驟 2021-10-31
- LaysanBio代理商相關文獻資料2020 2021-10-31
- click chemistry tools數據結果比... 2021-10-31
- Abbiotec代理的產品得到重複驗證2020 2021-10-31
- zyagen Laboratories代理的產品得到... 2021-06-20
- Toxin Technologies代理商相關文獻資... 2021-03-14
- 熱烈祝賀91麻豆福利视频网生物正式代理biocolor公司試劑產品... 2021-03-14
- 熱烈祝賀91麻豆福利视频网生物正式代理cytognos公司試劑產品... 2021-03-14
- Gelest代理的產品得到重複驗證2020 2021-03-14
