產品詳情
簡單介紹：
Anti-DPYSL2 antibody (60-115) (STJ500612)
詳情介紹：
| Host: | Rabbit |
| Applications: | ELISA/WB |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Rabbit polyclonal antibody anti-DPYSL2 (60-115) is suitable for use in ELISA and Western Blot research applications. |
| Clonality: | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Purification: | Affinity Purified |
| Concentration: | 0.57 µg/µl |
| Dilution Range: | WB: 1:500 DB: 1:10, 000 ELISA: 1:10, 000 |
| Storage Instruction: | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: | DPYSL2 |
| Gene ID: | 1808 |
| Uniprot ID: | DPYL2_HUMAN |
| Immunogen Region: | 60-115 |
| Immunogen: | Synthetic peptide taken from within the region corresponding to AA 60-115 of the CRMP2 protein. The 26mer peptide was conserved in several other species. The selected peptide was post-synthetically modified to achieve highest antigenicity before coup |
| Tissue Specificity | Ubiquitous. |
| Post Translational Modifications | 3F4, a monoclonal antibody which strongly stains neurofibrillary tangles in Alzheimer disease brains, specifically labels DPYSL2 when phosphorylated on Ser-518, Ser-522 and Thr-509. Phosphorylation at Thr-514 by GSK3B abolishes tubulin-binding leading to destabilization of microtubule assembly in axons and neurodegeneration. Phosphorylation by DYRK2 at Ser-522 is required for subsequent phosphorylation by GSK3B. |
| Function | Plays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal growth cone collapse and cell migration. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. May play a role in endocytosis. |
| Protein Name | Dihydropyrimidinase-Related Protein 2 Drp-2 Collapsin Response Mediator Protein 2 Crmp-2 N2a3 Unc-33-Like Phosphoprotein 2 Ulip-2 |
| Database Links | Reactome: R-HSA-399956 Reactome: R-HSA-437239 |
| Cellular Localisation | Cytoplasm Cytosol Cytoskeleton Membrane Tightly But Non-Covalently Associated With Membranes |
| Alternative Antibody Names | Anti-Dihydropyrimidinase-Related Protein 2 antibody Anti-Drp-2 antibody Anti-Collapsin Response Mediator Protein 2 antibody Anti-Crmp-2 antibody Anti-N2a3 antibody Anti-Unc-33-Like Phosphoprotein 2 antibody Anti-Ulip-2 antibody Anti-DPYSL2 antibody Anti-CRMP2 antibody Anti-ULIP2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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