Anti-DYRK1A antibody (300-350) (STJ500804) STJ500804-100|產品目錄|代理商|上海91麻豆福利视频网生物科技有限公司

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產品名稱：Anti-DYRK1A antibody (300-350) (STJ500804)
產品型號：STJ500804-100
產品廠商：ST john's laboratory
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簡單介紹：

Anti-DYRK1A antibody (300-350) (STJ500804)

詳情介紹：

Host:	Rabbit
Applications:	ELISA/IHC/IP/WB
Reactivity:	Human/Monkey/Mouse/Rat
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-DYRK1A (300-350) is suitable for use in ELISA, Immunohistochemistry, Immunoprecipitation and Western Blot research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Purification:	Affinity Purified
Concentration:	0.5 µg/µl
Dilution Range:	WB: 1:500 ELISA: 1:10, 000 IP: 1:150 IHC: 1:50-1:150
Storage Instruction:	Store at-20°C for long term storage. Avoid freeze-thaw cycles.

Gene Symbol:	DYRK1A
Gene ID:	1859
Uniprot ID:	DYR1A_HUMAN
Immunogen Region:	300-350
Immunogen:	Synthetic peptide taken within amino acid region 300-350 on human Dual specificity tyrosine-phosphorylation-regulated kinase 1A.

Tissue Specificity	Ubiquitous. Highest levels in skeletal muscle, testis, fetal lung and fetal kidney.
Post Translational Modifications	Autophosphorylated on numerous tyrosine residues. Can also autophosphorylate on serine and threonine residues (in vitro).
Function	Dual-specificity kinase which possesses both serine/threonine and tyrosine kinase activities. Exhibits a substrate preference for proline at position P+1 and arginine at position P-3. Plays an important role in double-strand breaks (DSBs) repair following DNA damage. Mechanistically, phosphorylates RNF169 and increases its ability to block accumulation of TP53BP1 at the DSB sites thereby promoting homologous recombination repair (HRR). Also acts as a positive regulator of transcription by acting as a CTD kinase that mediates phosphorylation of the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAP II) POLR2A. May play a role in a signaling pathway regulating nuclear functions of cell proliferation. Modulates alternative splicing by phosphorylating the splice factor SRSF6. Has pro-survival function and negatively regulates the apoptotic process. Promotes cell survival upon genotoxic stress through phosphorylation of SIRT1. This in turn inhibits p53/TP53 activity and apoptosis. Phosphorylates SEPTIN4, SEPTIN5 and SF3B1 at 'Thr-434'.
Protein Name	Dual Specificity Tyrosine-Phosphorylation-Regulated Kinase 1a Dual Specificity Yak1-Related Kinase Hp86 Protein Kinase Minibrain Homolog Mnbh Hmnb
Database Links	Reactome: R-HSA-1538133
Cellular Localisation	Nucleus Nucleus Speckle
Alternative Antibody Names	Anti-Dual Specificity Tyrosine-Phosphorylation-Regulated Kinase 1a antibody Anti-Dual Specificity Yak1-Related Kinase antibody Anti-Hp86 antibody Anti-Protein Kinase Minibrain Homolog antibody Anti-Mnbh antibody Anti-Hmnb antibody Anti-DYRK1A antibody Anti-DYRK antibody Anti-MNB antibody Anti-MNBH antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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產品名稱：Anti-DYRK1A antibody (300-350) (STJ500804)