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Anti-EEF2 antibody (1-290) (STJ114864) STJ114864|產品目錄|代理商|上海91麻豆福利视频网生物科技有限公司
產品詳情

  • 產品名稱：Anti-EEF2 antibody (1-290) (STJ114864)

  • 產品型號：STJ114864
  • 產品廠商：ST john's laboratory
  • 產品文檔：
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簡單介紹：
Anti-EEF2 antibody (1-290) (STJ114864)
詳情介紹：
Host: Rabbit
Applications: WB
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-EEF2 (1-290) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: EEF2
Gene ID: 1938
Uniprot ID: EF2_HUMAN
Immunogen Region: 1-290
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-290 of human eEF2 (NP_001952.1).
Immunogen Sequence: MVNFTVDQIRAIMDKKANIR NMSVIAHVDHGKSTLTDSLV CKAGIIASARAGETRFTDTR KDEQERCITIKSTAISLFYE LSENDLNFIKQSKDGAGFLI NLIDSPGHVDFSSEVTAALR VTDGALVVVDCVSGVCVQTE TVLRQAIAERIKPVLMMNKM DRALLELQLEPEELYQTFQR IVENVNVIISTYGEGESGPM GNImidpsVLGTVGFGSGLHG WAFTLKQFAEMYVAKFAAK
Post Translational Modifications Phosphorylation by EF-2 kinase completely inactivates EF-2.it requires prior phosphorylation by CDK2 at Ser-595 during mitotic prometaphase. Phosphorylation by CSK promotes SUMOylation, proteolytic cleavage, and nuclear translocations if the C-terminal fragment. Diphthamide is 2-3-carboxyamido-3-(trimethyl-ammonio)propylhistidine. (Microbial infection) Diphthamide can be ADP-ribosylated by diphtheria toxin and by Pseudomonas exotoxin A, thus arresting protein synthesis. ISGylated. Proteolytically processed at two sites following phosphorylation by CSK. SUMOylated following phosphorylation by CSK, promotes proteolytic cleavage.
Function Catalyzes the GTP-dependent ribosomal translocations step during translation elongation. During this step, the ribosome changes from the pre-translocationsal (PRE) to the post-translocationsal (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
Protein Name Elongation Factor 2
Ef-2
Database Links Reactome: R-HSA-156902
Reactome: R-HSA-5336415
Reactome: R-HSA-5358493
Reactome: R-HSA-6798695
Reactome: R-HSA-8876725
Cellular Localisation Cytoplasm
Nucleus
Phosphorylation By Csk Promotes Cleavage And Sumoylation-Dependent Nuclear Translocations Of The C-Terminal Cleavage Product
Alternative Antibody Names Anti-Elongation Factor 2 antibody
Anti-Ef-2 antibody
Anti-EEF2 antibody
Anti-EF2 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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