Anti-EEF2K antibody (406-725) (STJ27357) STJ27357|產品目錄|代理商|上海91麻豆福利视频网生物科技有限公司

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Anti-EEF2K antibody (406-725) (STJ27357)

詳情介紹：

Host:	Rabbit
Applications:	WB/IF
Reactivity:	Human/Mouse
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-EEF2K (406-725) is suitable for use in Western Blot and Immunofluorescence research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3.
Purification:	Affinity purification
Dilution Range:	WB 1:500-1:2000 IF/ICC 1:50-1:200
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	EEF2K
Gene ID:	29904
Uniprot ID:	EF2K_HUMAN
Immunogen Region:	406-725
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 406-725 of human EEF2K (NP_037434.1).
Immunogen Sequence:	KLDHLHWPVFSDLDNMASRD HDHLDNHRESENSGDSGYPS EKRGELDDPEPREHGHSYSN RKYESDEDSLGSSGRVCVEK WNLLNSSRLHLPRASAVALE VQRLNALDLEKKIGKSILGK VHLAMVRYHEGGRFCEKGEE WDQESAVFHLEHAANLGELE AIVGLGLMYSQLPHHILADV SLKETEENKTKGFDYLLKAA EAGDRQSMILVARAFDSGQN LSPDRCQDWLEALHWYNTA

Post Translational Modifications	Autophosphorylated at multiple residues, Thr-348 being the major site. Phosphorylated by AMP-activated protein kinase AMPK at Ser-398 leading to EEF2K activation and protein synthesis inhibition. Phosphorylated by TRPM7 at Ser-78 resulting in improved protein stability, higher EE2F phosphorylated and subsequently reduced rate of protein synthesis. Phosphorylation by other kinases such as CDK1 and MAPK13 at Ser-359 or RPS6KA1 and RPS6KB1 at Ser-366 instead decrease EEF2K activity and promote protein synthesis.
Function	Threonine kinase that regulates protein synthesis by controlling the rate of peptide chain elongation. Upon activation by a variety of upstream kinases including AMPK or TRPM7, phosphorylates the elongation factor EEF2 at a single site, renders it unable to bind ribosomes and thus inactive. In turn, the rate of protein synthesis is reduced.
Protein Name	Eukaryotic Elongation Factor 2 Kinase Eef-2 Kinase Eef-2k Calcium/Calmodulin-Dependent Eukaryotic Elongation Factor 2 Kinase
Database Links	Reactome: R-HSA-166208
Alternative Antibody Names	Anti-Eukaryotic Elongation Factor 2 Kinase antibody Anti-Eef-2 Kinase antibody Anti-Eef-2k antibody Anti-Calcium/Calmodulin-Dependent Eukaryotic Elongation Factor 2 Kinase antibody Anti-EEF2K antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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產品名稱：Anti-EEF2K antibody (406-725) (STJ27357)