Anti-EIF2AK2 antibody (413-462 aa) (STJ95144) STJ95144|產品目錄|代理商|上海91麻豆福利视频网生物科技有限公司

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產品名稱：Anti-EIF2AK2 antibody (413-462 aa) (STJ95144)
產品型號：STJ95144
產品廠商：ST john's laboratory
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簡單介紹：

Anti-EIF2AK2 antibody (413-462 aa) (STJ95144)

詳情介紹：

Host:	Rabbit
Applications:	WB/IHC/IF/ELISA
Reactivity:	Human/Rat/Mouse
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-Interferon-induced, double-stranded RNA-activated protein kinase (413-462 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:	1 mg/mL
Dilution Range:	WB 1:500-1:2000 IHC 1:100-1:300 ELISA 1:20000 IF 1:50-200
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	EIF2AK2
Gene ID:	5610
Uniprot ID:	E2AK2_HUMAN
Immunogen Region:	413-462 aa
Specificity:	PKR Polyclonal Antibody detects endogenous levels of PKR protein.
Immunogen:	The antiserum was produced against synthesized peptide derived from the human PKR at the amino acid range 413-462

Post Translational Modifications	Autophosphorylated on several Ser, Thr and Tyr residues. Autophosphorylation of Thr-451 is dependent on Thr-446 and is stimulated by dsRNA binding and dimerization. Autophosphorylation apparently leads to the activation of the kinase. Tyrosine autophosphorylation is essential for efficient dsRNA-binding, dimerization, and kinase activation.
Function	IFN-induced dsRNA-dependent serine/threonine-protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (EIF2S1/eIF-2-alpha) and plays a key role in the innate immune response to viral infection. Inhibits viral replication via the integrated stress response (ISR): EIF2S1/eIF-2-alpha phosphorylation in response to viral infection converts EIF2S1/eIF-2-alpha in a global protein synthesis inhibitor, resulting to a shutdown of cellular and viral protein synthesis, while concomitantly initiating the preferential translation of ISR-specific mRNAs, such as the transcriptional activator ATF4. Exerts its antiviral activity on a wide range of DNA and RNA viruses including hepatitis C virus (HCV), hepatitis B virus (HBV), measles virus (MV) and herpes simplex virus 1 (HHV-1). Also involved in the regulation of signal transduction, apoptosis, cell proliferation and differentiation: phosphorylates other substrates including p53/TP53, PPP2R5A, DHX9, ILF3, IRS1 and the HHV-1 viral protein US11. In addition to serine/threonine-protein kinase activity, also has tyrosine-protein kinase activity and phosphorylates CDK1 at 'Tyr-4' upon DNA damage, facilitating its ubiquitination and proteasomal degradation. Either as an adapter protein and/or via its kinase activity, can regulate various signaling pathways (p38 MAP kinase, NF-kappa-B and insulin signaling pathways) and transcription factors (JUN, STAT1, STAT3, IRF1, ATF3) involved in the expression of genes encoding pro-inflammatory cytokines and IFNs. Activates the NF-kappa-B pathway via interaction with IKBKB and TRAF family of proteins and activates the p38 MAP kinase pathway via interaction with MAP2K6. Can act as both a positive and negative regulator of the insulin signaling pathway (ISP). Negatively regulates ISP by inducing the inhibitory phosphorylation of insulin receptor substrate 1 (IRS1) at 'Ser-312' and positively regulates ISP via phosphorylation of PPP2R5A which activates FOXO1, which in turn up-regulates the expression of insulin receptor substrate 2 (IRS2). Can regulate NLRP3 inflammasome assembly and the activation of NLRP3, NLRP1, AIM2 and NLRC4 inflammasomes. Plays a role in the regulation of the cytoskeleton by binding to gelsolin (GSN), sequestering the protein in an inactive conformation away from actin.
Protein Name	Interferon-Induced - Double-Stranded Rna-Activated Protein Kinase Eukaryotic Translation Initiation Factor 2-Alpha Kinase 2 Eif-2a Protein Kinase 2 Interferon-Inducible Rna-Dependent Protein Kinase P1/Eif-2a Protein Kinase Protein Kinase Rna-Activated Pkr Protein Kinase R Tyrosine-Protein Kinase Eif2ak2 P68 Kinase
Database Links	Reactome: R-HSA-1169408 Reactome: R-HSA-169131 Reactome: R-HSA-909733
Cellular Localisation	Cytoplasm Nucleus Perinuclear Region Nuclear Localization Is Elevated In Acute Leukemia Myelodysplastic Syndrome (Mds) Melanoma Breast Colon Prostate And Lung Cancer Patient Samples Or Cell Lines As Well As Neurocytes From Advanced Creutzfeldt-Jakob Disease Patients
Alternative Antibody Names	Anti-Interferon-Induced - Double-Stranded Rna-Activated Protein Kinase antibody Anti-Eukaryotic Translation Initiation Factor 2-Alpha Kinase 2 antibody Anti-Eif-2a Protein Kinase 2 antibody Anti-Interferon-Inducible Rna-Dependent Protein Kinase antibody Anti-P1/Eif-2a Protein Kinase antibody Anti-Protein Kinase Rna-Activated antibody Anti-Pkr antibody Anti-Protein Kinase R antibody Anti-Tyrosine-Protein Kinase Eif2ak2 antibody Anti-P68 Kinase antibody Anti-EIF2AK2 antibody Anti-PKR antibody Anti-PRKR antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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產品名稱：Anti-EIF2AK2 antibody (413-462 aa) (STJ95144)