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Anti-EIF4E2 antibody (1-240) (STJ26609) STJ26609|產品目錄|代理商|上海91麻豆福利视频网生物科技有限公司
產品詳情

  • 產品名稱：Anti-EIF4E2 antibody (1-240) (STJ26609)

  • 產品型號：STJ26609
  • 產品廠商：ST john's laboratory
  • 產品文檔：
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簡單介紹：
Anti-EIF4E2 antibody (1-240) (STJ26609)
詳情介紹：
Host: Rabbit
Applications: WB/IHC/IF
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-EIF4E2 (1-240) is suitable for use in Western Blot, Immunohistochemistry and Immunofluorescence research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:1000
IHC-P 1:50-1:200
IF/ICC 1:50-1:200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: EIF4E2
Gene ID: 9470
Uniprot ID: IF4E2_HUMAN
Immunogen Region: 1-240
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-240 of human EIF4E2 (NP_004837.1).
Immunogen Sequence: MNNKFDALKDDDSGDHDQNE ENSTQKDGEKEKTERDKNQS SSKRKAVVPGPAEHPLQYNY TFWYSRRTPGRPTSSQSYEQ NIKQIGTFASVEQFWRFYSH MVRPGDLTGHSDFHLFKEGI KPMWEDDANKNGGKWIIRLR KGLASRCWENLILAMLGEQF MVGEEICGAVVSVRFQEDII SIWNKTASDQATTARIRDTL RRVLNLPPNTIMEYKTHTDS IKMPGRLGPQRLLFQNLWK
Post Translational Modifications Ubiquitinated by ARIH1. The consequences of ubiquitination are however unclear: according to a report, EIF4E2 ubiquitination leads to promote EIF4E2 cap-binding and protein translation arrest. According to another report ubiquitination leads to its subsequent degradation. ISGylation enhances its cap structure-binding activity and translation-inhibition activity.
Function Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation. Acts as a repressor of translation initiation. In contrast to EIF4E, it is unable to bind eIF4G (EIF4G1, EIF4G2 or EIF4G3), suggesting that it acts by competing with EIF4E and block assembly of eIF4F at the cap. In P-bodies, component of a complex that promotes miRNA-mediated translational repression. Involved in virus-induced host response by mediating miRNA MIR34A-induced translational silencing which controls IFNB1 production by a negative feedback mechanism. Component of the 4EHP-GYF2 complex, a multiprotein complex that acts as a repressor of translation initiation. In association with GIGYF2, assists ribosome-associated quality control (RQC) by sequestering the mRNA cap, blocking ribosome initiation and decreasing the translational load on problematic messages. Part of a pathway that works in parallel to RQC-mediated degradation of the stalled nascent polypeptide. GIGYF2 and EIF4E2 work downstream and independently of ZNF598, which seems to work as a scaffold that can recruit them to faulty mRNA even if alternative recruitment mechanisms may exist. (Microbial infection) Upon SARS coronavirus-2/SARS-CoV-2 infection, the interaction with non-structural protein 2 (nsp2) with GIGYF2 enhances GIGYF2 binding to EIF4E2 and increases repression of translation initiation of genes involved in antiviral innate immune response such as IFNB1.
Protein Name Eukaryotic Translation Initiation Factor 4e Type 2
Eif-4e Type 2
Eif4e Type 2
Eukaryotic Translation Initiation Factor 4e Homologous Protein
Eukaryotic Translation Initiation Factor 4e-Like 3
Eif4e-Like Protein 4e-Lp
Mrna Cap-Binding Protein 4ehp
H4ehp
Mrna Cap-Binding Protein Type 3
Database Links Reactome: R-HSA-1169408
Cellular Localisation Cytoplasm
P-Body
Alternative Antibody Names Anti-Eukaryotic Translation Initiation Factor 4e Type 2 antibody
Anti-Eif-4e Type 2 antibody
Anti-Eif4e Type 2 antibody
Anti-Eukaryotic Translation Initiation Factor 4e Homologous Protein antibody
Anti-Eukaryotic Translation Initiation Factor 4e-Like 3 antibody
Anti-Eif4e-Like Protein 4e-Lp antibody
Anti-Mrna Cap-Binding Protein 4ehp antibody
Anti-H4ehp antibody
Anti-Mrna Cap-Binding Protein Type 3 antibody
Anti-EIF4E2 antibody
Anti-EIF4EL3 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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