Anti-CD51/Itgav antibody [RMV-7] {PE/Cyanine7} (STJA0002588) STJA0002588|產品目錄|代理商|上海91麻豆福利视频网生物科技有限公司

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產品名稱：Anti-CD51/Itgav antibody [RMV-7] {PE/Cyanine7} (STJA0002588)
產品型號：STJA0002588
產品廠商：ST john's laboratory
產品文檔：

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簡單介紹：

Anti-CD51/Itgav antibody [RMV-7] {PE/Cyanine7} (STJA0002588)

詳情介紹：

Host:	Rat
Applications:	FC
Reactivity:	Mouse
Note:	FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS.
Short Description:	Rat monoclonal antibody anti-Integrin alpha-V is suitable for use in Flow Cytometry research applications.

Clonality:	Monoclonal
Clone ID:	RMV-7
Conjugation:	PE/Cyanine7
Isotype:	IgG1k
Formulation:	PBS with 0.05% Proclin300, 1% BSA
Storage Instruction:	Recommend storing between 2-8°C and protecting from prolonged exposure to light. Do not freeze this product.

Gene Symbol:	Itgav
Gene ID:	16410
Uniprot ID:	ITAV_MOUSE

Function	The alpha-V (ITGAV) integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, TGFB1 and vWF. They recognize the sequence R-G-D in a wide array of ligands. Alpha-V integrins may play a role in embryo implantation, angiogenesis and wound healing. ITGAV:ITGB3 binds to fractalkine (CX3CL1) and may act as its coreceptor in CX3CR1-dependent fractalkine signaling. ITGAV:ITGB3 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling. ITGAV:ITGB3 binds to FGF1 and this binding is essential for FGF1 signaling. ITGAV:ITGB3 binds to FGF2 and this binding is essential for FGF2 signaling. ITGAV:ITGB3 binds to IGF1 and this binding is essential for IGF1 signaling. ITGAV:ITGB3 binds to IGF2 and this binding is essential for IGF2 signaling. ITGAV:ITGB3 binds to IL1B and this binding is essential for IL1B signaling. ITGAV:ITGB3 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1. ITGAV:ITGB3 and ITGAV:ITGB6 act as a receptor for fibrillin-1 (FBN1) and mediate R-G-D-dependent cell adhesion to FBN1. Integrin alpha-V/beta-6 or alpha-V/beta-8 (ITGAV:ITGB6 or ITGAV:ITGB8) mediates R-G-D-dependent release of transforming growth factor beta-1 (TGF-beta-1) from regulatory Latency-associated peptide (LAP), thereby playing a key role in TGF-beta-1 activation. ITGAV:ITGB3 acts as a receptor for CD40LG. ITGAV:ITGB3 binds to the Lilrb4a/Gp49b receptor and enhances the Lilrb4a-mediated inhibition of mast cell activation. ITGAV:ITGB3 also suppresses marginal zone B cell antibody production through its interaction with Lilrb4a.
Protein Name	Integrin Alpha-V Vitronectin Receptor Subunit Alpha Cd Antigen Cd51 Cleaved Into - Integrin Alpha-V Heavy Chain - Integrin Alpha-V Light Chain
Database Links	Reactome: R-MMU-1236973 Reactome: -MMU-1566948 Reactome: -MMU-210990 Reactome: -MMU-2129379 Reactome: -MMU-216083 Reactome: -MMU-2173789 Reactome: -MMU-3000170 Reactome: -MMU-3000178 Reactome: -MMU-4420097 Reactome: -MMU-445144 Reactome: -MMU-6798695
Cellular Localisation	Cell Membrane Single-Pass Type I Membrane Protein Cell Junction Focal Adhesion
Alternative Antibody Names	Anti-Integrin Alpha-V antibody Anti-Vitronectin Receptor Subunit Alpha antibody Anti-Cd Antigen Cd51 Cleaved Into - Integrin Alpha-V Heavy Chain - Integrin Alpha-V Light Chain antibody Anti-Itgav antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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產品名稱：Anti-CD51/Itgav antibody [RMV-7] {PE/Cyanine7} (STJA0002588)