Anti-ELOB antibody (1-100) [S4190RM] (STJ11104190) STJ11104190|產品目錄|代理商|上海91麻豆福利视频网生物科技有限公司

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產品名稱：Anti-ELOB antibody (1-100) [S4190RM] (STJ11104190)
產品型號：STJ11104190
產品廠商：ST john's laboratory
產品文檔：

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Anti-ELOB antibody (1-100) [S4190RM] (STJ11104190)

詳情介紹：

Host:	Rabbit
Applications:	WB
Reactivity:	Human/Mouse/Rat
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit monoclonal antibody anti-Elongin-B (1-100) is suitable for use in Western Blot research applications.

Clonality:	Monoclonal
Clone ID:	S4190RM
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH7.3.
Purification:	Affinity purification
Dilution Range:	WB 1:500-1:1000
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	ELOB
Gene ID:	6923
Uniprot ID:	ELOB_HUMAN
Immunogen Region:	1-100
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 1-100 of human TCEB2 (NP_009039.1).
Immunogen Sequence:	MDVFLMIRRHKTTIFTDAKE SSTVFELKRIVEGILKRPPD EQRLYKDDQLLDDGKTLGEC GFTSQTARPQAPATVGLAFR ADDTFEALCIEPFSSPPELP

Function	SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex). In embryonic stem cells, the elongin BC complex is recruited by EPOP to Polycomb group (PcG) target genes in order generate genomic region that display both active and repressive chromatin properties, an important feature of pluripotent stem cells. Core component of multiple cullin-RING-based ECS (ElonginB/C-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins. This includes the von Hippel-Lindau ubiquitination complex CBC(VHL). By binding to BC-box motifs it seems to link target recruitment subunits, like VHL and members of the SOCS box family, to Cullin/RBX1 modules that activate E2 ubiquitination enzymes. As part of a multisubunit ubiquitin ligase complex composed of elongin BC complex (ELOB and ELOC), elongin A/ELOA, RBX1 and CUL5.polyubiquitinates monoubiquitinated POLR2A. A number of ECS complexes (containing either KLHDC2, KLHDC3, KLHDC10, APPBP2, FEM1A, FEM1B or FEM1C as substrate-recognition component) are part of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation. ECS(LRR1) ubiquitinates MCM7 and promotes CMG replisome disassembly by VCP and chromatin extraction during S-phase.
Protein Name	Elongin-B Elob Elongin 18 Kda Subunit Rna Polymerase Ii Transcription Factor Siii Subunit B Siii P18 Transcription Elongation Factor B Polypeptide 2
Database Links	Reactome: R-HSA-112382 Reactome: R-HSA-1234176 Reactome: R-HSA-167152 Reactome: R-HSA-167200 Reactome: R-HSA-167238 Reactome: R-HSA-167243 Reactome: R-HSA-167246 Reactome: R-HSA-167287 Reactome: R-HSA-167290 Reactome: R-HSA-180585 Reactome: R-HSA-674695 Reactome: R-HSA-6796648 Reactome: R-HSA-75955 Reactome: R-HSA-8951664 Reactome: R-HSA-9010553 Reactome: R-HSA-9705462 Reactome: R-HSA-983168
Cellular Localisation	Nucleus
Alternative Antibody Names	Anti-Elongin-B antibody Anti-Elob antibody Anti-Elongin 18 Kda Subunit antibody Anti-Rna Polymerase Ii Transcription Factor Siii Subunit B antibody Anti-Siii P18 antibody Anti-Transcription Elongation Factor B Polypeptide 2 antibody Anti-ELOB antibody Anti-TCEB2 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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產品名稱：Anti-ELOB antibody (1-100) [S4190RM] (STJ11104190)