Anti-EPHA2 antibody (Extracellular region) [M088] (STJA0005403) STJA0005403-100|產品目錄|代理商|上海91麻豆福利视频网生物科技有限公司

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產品名稱：Anti-EPHA2 antibody (Extracellular region) [M088] (STJA0005403)
產品型號：STJA0005403-100
產品廠商：ST john's laboratory
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Anti-EPHA2 antibody (Extracellular region) [M088] (STJA0005403)

詳情介紹：

Host:	Mouse
Applications:	ICC/IP
Reactivity:	Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Mouse monoclonal antibody anti-EphA2 M088 (Extracellular region) is suitable for use in Immunocytochemistry and Immunoprecipitation research applications.

Clonality:	Monoclonal
Clone ID:	M088
Conjugation:	Unconjugated
Isotype:	IgG1
Formulation:	PBS + 1 mg/ml BSA, 0.05% NaN3 and 50% glycerol
Purification:	Antigen Affinity Purified
Dilution Range:	WB IHC ICC 1:200 IP 1:100
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	EPHA2
Gene ID:	1969
Uniprot ID:	EPHA2_HUMAN
Immunogen Region:	Extracellular region
Specificity:	Clone M088 mouse monoclonal antibody detects native human EphA2, as well as aldehyde-fixed EphA2. The antibody works for staining in immunocytochemistry, capture and detection in ELISA, and native immunoprecipitation assays.
Immunogen:	Clone (M088) was generated from a recombinant protein that included the extracellular region of human EphA2 protein.

Tissue Specificity	Expressed in brain and glioma tissue and glioma cell lines (at protein level). Expressed most highly in tissues that contain a high proportion of epithelial cells, e.g. skin, intestine, lung, and ovary.
Post Translational Modifications	Autophosphorylates. Phosphorylated on tyrosine upon binding and activation by EFNA1. Phosphorylated residues Tyr-588 and Tyr-594 are required for binding VAV2 and VAV3 while phosphorylated residues Tyr-735 and Tyr-930 are required for binding PI3-kinase p85 subunit (PIK3R1, PIK3R2 or PIK3R3). These phosphorylated residues are critical for recruitment of VAV2 and VAV3 and PI3-kinase p85 subunit which transduce downstream signaling to activate RAC1 GTPase and cell migration. Dephosphorylation of Tyr-930 by PTPRF prevents the interaction of EPHA2 with NCK1. Phosphorylated at Ser-897 by PKB.serum-induced phosphorylation which targets EPHA2 to the cell leading edge and stimulates cell migration. Phosphorylation by PKB is inhibited by EFNA1-activated EPHA2 which regulates PKB activity via a reciprocal regulatory loop. Phosphorylated at Ser-897 in response to TNF by RPS6KA1 and RPS6KA3.RPS6KA-EPHA2 signaling pathway controls cell migration. Phosphorylated at Ser-897 by PKA.blocks cell retraction induced by EPHA2 kinase activity. Dephosphorylated by ACP1. Ubiquitinated by CHIP/STUB1. Ubiquitination is regulated by the HSP90 chaperone and regulates the receptor stability and activity through proteasomal degradation. ANKS1A prevents ubiquitination and degradation.
Function	Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Activated by the ligand ephrin-A1/EFNA1 regulates migration, integrin-mediated adhesion, proliferation and differentiation of cells. Regulates cell adhesion and differentiation through DSG1/desmoglein-1 and inhibition of the ERK1/ERK2 (MAPK3/MAPK1, respectively) signaling pathway. May also participate in UV radiation-induced apoptosis and have a ligand-independent stimulatory effect on chemotactic cell migration. During development, may function in distinctive aspects of pattern formation and subsequently in development of several fetal tissues. Involved for instance in angiogenesis, in early hindbrain development and epithelial proliferation and branching morphogenesis during mammary gland development. Engaged by the ligand ephrin-A5/EFNA5 may regulate lens fiber cells shape and interactions and be important for lens transparency development and maintenance. With ephrin-A2/EFNA2 may play a role in bone remodeling through regulation of osteoclastogenesis and osteoblastogenesis. (Microbial infection) Acts as a receptor for hepatitis C virus (HCV) in hepatocytes and facilitates its cell entry. Mediates HCV entry by promoting the formation of the CD81-CLDN1 receptor complexes that are essential for HCV entry and by enhancing membrane fusion of cells expressing HCV envelope glycoproteins. Acts as a receptor for human cytomegalovirus (HCMV) to mediate viral entry and fusion in glioblastoma cells.
Protein Name	Ephrin Type-A Receptor 2 Epithelial Cell Kinase Tyrosine-Protein Kinase Receptor Eck
Database Links	Reactome: R-HSA-2682334 Reactome: R-HSA-3928663 Reactome: R-HSA-3928665 Reactome: R-HSA-9013149 Reactome: R-HSA-9013404 Reactome: R-HSA-9013408 Reactome: R-HSA-9013420 Reactome: R-HSA-9013423 Reactome: R-HSA-9013424 Reactome: R-HSA-9696264 Reactome: R-HSA-9696270 Reactome: R-HSA-9696273
Cellular Localisation	Cell Membrane Single-Pass Type I Membrane Protein Cell Projection Ruffle Membrane Lamellipodsium Membrane Cell Junction Focal Adhesion Present At Regions Of Cell-Cell Contacts But Also At The Leading Edge Of Migrating Cells Relocates From The Plasma Membrane To The Cytoplasmic And Perinuclear Regions In Cancer Cells
Alternative Antibody Names	Anti-Ephrin Type-A Receptor 2 antibody Anti-Epithelial Cell Kinase antibody Anti-Tyrosine-Protein Kinase Receptor Eck antibody Anti-EPHA2 antibody Anti-ECK antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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產品名稱：Anti-EPHA2 antibody (Extracellular region) [M088] (STJA0005403)