Anti-EPM2A antibody (244-331) (STJ29087) STJ29087|產品目錄|代理商|上海91麻豆福利视频网生物科技有限公司

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產品名稱：Anti-EPM2A antibody (244-331) (STJ29087)
產品型號：STJ29087
產品廠商：ST john's laboratory
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簡單介紹：

Anti-EPM2A antibody (244-331) (STJ29087)

詳情介紹：

Host:	Rabbit
Applications:	WB
Reactivity:	Human/Mouse/Rat
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-EPM2A (244-331) is suitable for use in Western Blot research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3.
Purification:	Affinity purification
Dilution Range:	WB 1:500-1:2000
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	EPM2A
Gene ID:	7957
Uniprot ID:	EPM2A_HUMAN
Immunogen Region:	244-331
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 244-331 of human EPM2A (NP_005661.1).
Immunogen Sequence:	MLPQAVCLLHALLEKGHIVY VHCNAGVGRSTAAVCGWLQY VMGWNLRKVQYFLMAKRPAV YIDEEALARAQEDFFQKFGK VRSSVCSL

Tissue Specificity	Expressed in heart, skeletal muscle, kidney, pancreas and brain. Isoform 4 is also expressed in the placenta.
Post Translational Modifications	Polyubiquitinated by NHLRC1/malin. Phosphorylation on Ser-25 by AMPK affects the phosphatase activity of the enzyme and its ability to homodimerize and interact with NHLRC1, PPP1R3C or PRKAA2.
Function	Plays an important role in preventing glycogen hyperphosphorylation and the formation of insoluble aggregates, via its activity as glycogen phosphatase, and by promoting the ubiquitination of proteins involved in glycogen metabolism via its interaction with the E3 ubiquitin ligase NHLRC1/malin. Shows strong phosphatase activity towards complex carbohydrates in vitro, avoiding glycogen hyperphosphorylation which is associated with reduced branching and formation of insoluble aggregates. Dephosphorylates phosphotyrosine and synthetic substrates, such as para-nitrophenylphosphate (pNPP), and has low activity with phosphoserine and phosphothreonine substrates (in vitro). Has been shown to dephosphorylate MAPT. Forms a complex with NHLRC1/malin and HSP70, which suppresses the cellular toxicity of misfolded proteins by promoting their degradation through the ubiquitin-proteasome system (UPS). Acts as a scaffold protein to facilitate PPP1R3C/PTG ubiquitination by NHLRC1/malin. Also promotes proteasome-independent protein degradation through the macroautophagy pathway. Isoform 2: Does not bind to glycogen. Lacks phosphatase activity and might function as a dominant-negative regulator for the phosphatase activity of isoform 1 and isoform 7. Isoform 7: Has phosphatase activity (in vitro).
Protein Name	Laforin Glucan Phosphatase Glycogen Phosphatase Lafora Ptpase Lafptpase
Database Links	Reactome: R-HSA-3322077 Reactome: R-HSA-3785653
Cellular Localisation	Cytoplasm Under Glycogenolytic Conditions Localizes To The Nucleus Isoform 1: Cytoplasm Endoplasmic Reticulum Membrane Peripheral Membrane Protein Cytoplasmic Side Cell Membrane Colocalizes With Glycogen Synthase In Punctate Structures In The Cytoplasm Primarily Associated With Polyribosomes At The Rough Endoplasmic Reticulum And Also Detected At The Plasma Membrane Isoform 2: Cytoplasm Nucleus Also Found In The Nucleus Isoform 4: Cytoplasm Isoform 5: Cytoplasm Isoform 7: Cytoplasm
Alternative Antibody Names	Anti-Laforin antibody Anti-Glucan Phosphatase antibody Anti-Glycogen Phosphatase antibody Anti-Lafora Ptpase antibody Anti-Lafptpase antibody Anti-EPM2A antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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產品名稱：Anti-EPM2A antibody (244-331) (STJ29087)