Anti-ESRRA antibody (1-100) [S1MR] (STJ11102011) STJ11102011|產品目錄|代理商|上海91麻豆福利视频网生物科技有限公司

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產品名稱：Anti-ESRRA antibody (1-100) [S1MR] (STJ11102011)
產品型號：STJ11102011
產品廠商：ST john's laboratory
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簡單介紹：

Anti-ESRRA antibody (1-100) [S1MR] (STJ11102011)

詳情介紹：

Host:	Rabbit
Applications:	WB
Reactivity:	Human/Mouse
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit monoclonal antibody anti-Estrogen Related Receptor alpha (1-100) is suitable for use in Western Blot research applications.

Clonality:	Monoclonal
Clone ID:	S1MR
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH7.3.
Purification:	Affinity purification
Dilution Range:	WB 1:500-1:1000
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	ESRRA
Gene ID:	2101
Uniprot ID:	ERR1_HUMAN
Immunogen Region:	1-100
Immunogen:	A synthetic peptide corresponding to a sequence within amino acids 1-100 of human ESRRA (P11474).
Immunogen Sequence:	MSSQVVGIEPLYIKAEPASP DSPKGSSETETEPPVALAPG PAPTRCLPGHKEEEDGEGAG PGEQGGGKLVLSSLPKRLCL VCGDVASGYHYGVASCEACK

Post Translational Modifications	Phosphorylation on Ser-19 enhances sumoylation on Lys-14 increasing repression of transcriptional activity. Sumoylated with SUMO2. Main site is Lys-14 which is enhanced by phosphorylation on Ser-19, cofactor activation, and by interaction with PIAS4. Sumoylation enhances repression of transcriptional activity, but has no effect on subcellular locations nor on DNA binding. Reversibly acetylated. Acetylation by PCAF/KAT2 at Lys-129, Lys-138, Lys-160 and Lys-162 and PCAF/KAT2 decreases transcriptional activity probably by inhibiting DNA-binding activity.deacetylation involves SIRT1 and HDAC8 and increases DNA-binding.
Function	Binds to an ERR-alpha response element (ERRE) containing a single consensus half-site, 5'-TNAAGGTCA-3'. Can bind to the medium-chain acyl coenzyme A dehydrogenase (MCAD) response element NRRE-1 and may act as an important regulator of MCAD promoter. Binds to the C1 region of the lactoferrin gene promoter. Requires dimerization and the coactivator, PGC-1A, for full activity. The ERRalpha/PGC1alpha complex is a regulator of energy metabolism. Induces the expression of PERM1 in the skeletal muscle.
Protein Name	Steroid Hormone Receptor Err1 Estrogen Receptor-Like 1 Estrogen-Related Receptor Alpha Err-Alpha Nuclear Receptor Subfamily 3 Group B Member 1
Database Links	Reactome: R-HSA-1989781 Reactome: R-HSA-2151201 Reactome: R-HSA-383280 Reactome: R-HSA-8939902
Cellular Localisation	Nucleus Cytoplasm Co-Localizes To The Cytoplasm Only In Presence Of Mapk15
Alternative Antibody Names	Anti-Steroid Hormone Receptor Err1 antibody Anti-Estrogen Receptor-Like 1 antibody Anti-Estrogen-Related Receptor Alpha antibody Anti-Err-Alpha antibody Anti-Nuclear Receptor Subfamily 3 Group B Member 1 antibody Anti-ESRRA antibody Anti-ERR1 antibody Anti-ESRL1 antibody Anti-NR3B1 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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產品名稱：Anti-ESRRA antibody (1-100) [S1MR] (STJ11102011)