產品詳情
簡單介紹：
Anti-CD86 antibody (STJ11105173)
詳情介紹：
| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Rabbit polyclonal antibody anti-CD86 is suitable for use in Western Blot research applications. |
| Clonality: | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: | Affinity purification |
| Dilution Range: | WB 1:1000-1:5000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | Cd86 |
| Gene ID: | 12524 |
| Uniprot ID: | CD86_MOUSE |
| Immunogen: | Recombinant protein of mouse CD86. |
| Tissue Specificity | Expressed on activated B-cells. |
| Post Translational Modifications | Polyubiquitinated.which is promoted by MARCH8 and results in endocytosis and lysosomal degradation. |
| Function | Receptor involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4. May play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T-cells within 24 hours after activation. Also involved in the regulation of B cells function, plays a role in regulating the level of IgG(1) produced. Upon CD40 engagement, activates NF-kappa-B signaling pathway via phospholipase C and protein kinase C activation. |
| Protein Name | T-Lymphocyte Activation Antigen Cd86 Activation B7-2 Antigen Early T-Cell Costimulatory Molecule 1 Etc-1 Cd Antigen Cd86 |
| Database Links | Reactome: R-MMU-1257604 Reactome: -MMU-389356 Reactome: -MMU-389357 Reactome: -MMU-389359 Reactome: -MMU-389513 Reactome: -MMU-6811558 |
| Cellular Localisation | Cell Membrane Single-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-T-Lymphocyte Activation Antigen Cd86 antibody Anti-Activation B7-2 Antigen antibody Anti-Early T-Cell Costimulatory Molecule 1 antibody Anti-Etc-1 antibody Anti-Cd Antigen Cd86 antibody Anti-Cd86 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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