Mouse TFR (Transferrin Receptor) Sandwich ELISA Kit (STJE0012495) STJE0012495|產品目錄|代理商|上海91麻豆福利视频网生物科技有限公司

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產品名稱：Mouse TFR (Transferrin Receptor) Sandwich ELISA Kit (STJE0012495)
產品型號：STJE0012495
產品廠商：ST john's laboratory
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簡單介紹：

Mouse TFR (Transferrin Receptor) Sandwich ELISA Kit (STJE0012495)

詳情介紹：

Applications:	ELISA
Reactivity:	Mouse
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity:	0.28ng/mL
Detection Limit:	0.781-50ng/mL
Short Description:	This TFR Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in mouse cell culture supernatant, serum and plasma (EDTA, citrate, heparin).

Storage Instruction:	Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time:	4.5 hrs

Gene Symbol:	Tfrc
Gene ID:	22042
Uniprot ID:	TFR1_MOUSE
Sample Type:	serum, plasma, tissue homogenates or other biological fluids.

Tissue Specificity
Post Translational Modifications	Stearoylated by ZDHHC6 which inhibits TFRC-mediated activation of the JNK pathway and promotes mitochondrial fragmentation. Stearoylation does not affect iron uptake. N- and O-glycosylated, phosphorylated and palmitoylated.
Function	Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system. Upon stimulation, positively regulates T and B cell proliferation through iron uptake. Acts as a lipid sensor that regulates mitochondrial fusion by regulating activation of the JNK pathway. When dietary levels of stearate (C18:0) are low, promotes activation of the JNK pathway, resulting in HUWE1-mediated ubiquitination and subsequent degradation of the mitofusin MFN2 and inhibition of mitochondrial fusion. When dietary levels of stearate (C18:0) are high, TFRC stearoylation inhibits activation of the JNK pathway and thus degradation of the mitofusin MFN2.
Protein Name	Transferrin Receptor Protein 1 Tr Tfr Tfr1 Trfr Cd Antigen Cd71
Database Links	Reactome: R-MMU-432722 Reactome: -MMU-8856825 Reactome: -MMU-8856828 Reactome: -MMU-8980692 Reactome: -MMU-9013026 Reactome: -MMU-9013106 Reactome: -MMU-9013149 Reactome: -MMU-9013404 Reactome: -MMU-9013406 Reactome: -MMU-9013407 Reactome: -MMU-9013408 Reactome: -MMU-9013423 Reactome: -MMU-917977 Reactome: -MMU-9696270 Reactome: -MMU-9696273
Cellular Localisation	Cell Membrane Single-Pass Type Ii Membrane Protein Melanosome
Alternative ELISA Names	Transferrin Receptor Protein 1 ELISA kit Tr ELISA kit Tfr ELISA kit Tfr1 ELISA kit Trfr ELISA kit Cd Antigen Cd71 ELISA kit Tfrc ELISA kit Trfr ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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產品名稱：Mouse TFR (Transferrin Receptor) Sandwich ELISA Kit (STJE0012495)