Anti-EZR antibody (511-560 aa) (STJ93016) STJ93016|產品目錄|代理商|上海91麻豆福利视频网生物科技有限公司

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Anti-EZR antibody (511-560 aa) (STJ93016)

詳情介紹：

Host:	Rabbit
Applications:	WB/IF/ELISA
Reactivity:	Human/Mouse/Rat
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-Ezrin (511-560 aa) is suitable for use in Western Blot, Immunofluorescence and ELISA research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:	1 mg/mL
Dilution Range:	WB 1:500-1:2000 ELISA 1:20000 IF 1:50-200
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	EZR
Gene ID:	7430
Uniprot ID:	EZRI_HUMAN
Immunogen Region:	511-560 aa
Specificity:	Ezrin Polyclonal Antibody detects endogenous levels of Ezrin protein.
Immunogen:	The antiserum was produced against synthesized peptide derived from the human Ezrin at the amino acid range 511-560

Post Translational Modifications	Phosphorylated by tyrosine-protein kinases. Phosphorylation by ROCK2 suppresses the head-to-tail association of the N-terminal and C-terminal halves resulting in an opened conformation which is capable of actin and membrane-binding. S-nitrosylation is induced by interferon-gamma and oxidatively-modified low-densitity lipoprotein (LDL(ox)) possibly implicating the iNOS-S100A8/9 transnitrosylase complex.
Function	Probably involved in connections of major cytoskeletal structures to the plasma membrane. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with PLEKHG6, required for normal macropinocytosis.
Protein Name	Ezrin Cytovillin Villin-2 P81
Database Links	Reactome: R-HSA-373752 Reactome: R-HSA-437239 Reactome: R-HSA-9662360 Reactome: R-HSA-9662361
Cellular Localisation	Apical Cell Membrane Peripheral Membrane Protein Cytoplasmic Side Cell Projection Microvillus Membrane Ruffle Membrane Cytoplasm Cell Cortex Cytoskeleton Microvillus Localization To The Apical Membrane Of Parietal Cells Depends On The Interaction With Pals1 Localizes To Cell Extensions And Peripheral Processes Of Astrocytes Microvillar Peripheral Membrane Protein (Cytoplasmic Side)
Alternative Antibody Names	Anti-Ezrin antibody Anti-Cytovillin antibody Anti-Villin-2 antibody Anti-P81 antibody Anti-EZR antibody Anti-VIL2 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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產品名稱：Anti-EZR antibody (511-560 aa) (STJ93016)