產品詳情
簡單介紹：
Anti-FCER1A antibody (26-205) (STJ23638)
詳情介紹：
| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Rabbit polyclonal antibody anti-FCER1A (26-205) is suitable for use in Western Blot research applications. |
| Clonality: | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: | Affinity purification |
| Dilution Range: | WB 1:500-1:2000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | FCER1A |
| Gene ID: | 2205 |
| Uniprot ID: | FCERA_HUMAN |
| Immunogen Region: | 26-205 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 26-205 of human FCER1A (NP_001992.1). |
| Immunogen Sequence: | VPQKPKVSLNPPWNRIFKGE NVTLTCNGNNFFEVSSTKWF HNGSLSEETNSSLNIVNAKF EDSGEYKCQHQQVNESEPVY LEVFSDWLLLQASAEVVMEG QPLFLRCHGWRNWDVYKVIY YKDGEALKYWYENHNISITN ATVEDSGTYYCTGKVWQLDY ESEPLNITVIKAPREKYWLQ |
| Tissue Specificity | Expressed in eosinophils. |
| Function | High-affinity receptor for immunoglobulin epsilon/IgE. Mediates IgE effector functions in myeloid cells. Upon IgE binding and antigen/allergen cross-linking initiates signaling pathways that lead to myeloid cell activation and differentiation. On mast cells, basophils and eosinophils stimulates the secretion of vasoactive amines, lipid mediators and cytokines that contribute to inflammatory response, tissue remodeling and cytotoxicity against microbes. Triggers the immediate hypersensitivity response to allergens as a host defense mechanism against helminth parasites, pathogenic bacteria and venom toxicity. When dysregulated, it can elicit harmful life-threatening allergic and anaphylactic reactions. |
| Protein Name | High Affinity Immunoglobulin Epsilon Receptor Subunit Alpha Fc-Epsilon Ri-Alpha Fceri Ige Fc Receptor Subunit Alpha |
| Database Links | Reactome: R-HSA-2454202 Reactome: R-HSA-2730905 Reactome: R-HSA-2871796 Reactome: R-HSA-2871809 Reactome: R-HSA-2871837 |
| Cellular Localisation | Cell Membrane Single-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-High Affinity Immunoglobulin Epsilon Receptor Subunit Alpha antibody Anti-Fc-Epsilon Ri-Alpha antibody Anti-Fceri antibody Anti-Ige Fc Receptor Subunit Alpha antibody Anti-FCER1A antibody Anti-FCE1A antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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