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Anti-FCHO2 antibody (1-300) (STJ117155) STJ117155|產品目錄|代理商|上海91麻豆福利视频网生物科技有限公司
產品詳情

  • 產品名稱：Anti-FCHO2 antibody (1-300) (STJ117155)

  • 產品型號：STJ117155
  • 產品廠商：ST john's laboratory
  • 產品文檔：
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簡單介紹：
Anti-FCHO2 antibody (1-300) (STJ117155)
詳情介紹：
Host: Rabbit
Applications: WB
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-FCHO2 (1-300) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: FCHO2
Gene ID: 115548
Uniprot ID: FCHO2_HUMAN
Immunogen Region: 1-300
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human FCHO2 (NP_620137.2).
Immunogen Sequence: MVMAYFVENFWGEKNSGFDV LYHNMKHGQISTKELADFVR ERATIEEAYSRSMTKLAKSA SNYSQLGTFAPVWDVFKTST EKLANCHLDLVRKLQELIKE VQKYGEEQVKSHKKTKEEVA GTLEAVQTIQSITQALQKSK ENYNAKCVEQERLKKEGATQ REIEKAAVKSKKATDTYKLY VEKYALAKADFEQKMTETAQ KFQDIEETHLIHIKEIIGSL SNAIKEIHLQIGQVHEEFI
Post Translational Modifications Ubiquitinated. Mainly undergoes monoubiquitination but also polyubiquitination.
Function Functions in an early step of clathrin-mediated endocytosis. Has both a membrane binding/bending activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. Has a lipid-binding activity with a preference for membranes enriched in phosphatidylserine and phosphoinositides (Pi(4,5) biphosphate) like the plasma membrane. Its membrane-bending activity might be important for the subsequent action of clathrin and adaptors in the formation of clathrin-coated vesicles. Involved in adaptor protein complex AP-2-dependent endocytosis of the transferrin receptor, it also functions in the AP-2-independent endocytosis of the LDL receptor.
Protein Name F-Bar Domain Only Protein 2
Database Links Reactome: R-HSA-8856825
Reactome: R-HSA-8856828
Cellular Localisation Membrane
Clathrin-Coated Pit
Peripheral Membrane Protein
Cytoplasmic Side
Associated With Forming But Not Mature Clathrin-Coated Vesicles
The Recruitment To Coated-Pits Precede The One Of Clathrin And The Adaptor Protein Complex Ap-2
Alternative Antibody Names Anti-F-Bar Domain Only Protein 2 antibody
Anti-FCHO2 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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