產品詳情
簡單介紹:
Anti-CDH23 antibody (40-270) (STJ23045)
詳情介紹:
Host: | Rabbit |
Applications: | WB |
Reactivity: | Human/Mouse/Rat |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description: | Rabbit polyclonal antibody anti-CDH23 (40-270) is suitable for use in Western Blot research applications. |
Clonality: | Polyclonal |
Conjugation: | Unconjugated |
Isotype: | IgG |
Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
Purification: | Affinity purification |
Dilution Range: | WB 1:200-1:1000 |
Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Gene Symbol: | CDH23 |
Gene ID: | 64072 |
Uniprot ID: | CAD23_HUMAN |
Immunogen Region: | 40-270 |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 40-270 of human CDH23 (NP_001165402.1). |
Immunogen Sequence: | LLISEDTPVGSSVTQLLAQD MDNDPLVFGVSGEEASRFFA VEPDTGVVWLRQPLDRETKS EFTVEFSVSDHQGVITRKVN IQVGDVNDNAPTFHNQPYSV RIPENTPVGTPIFIVNATDP DLGAGGSVLYSFQPPSQFFA IDSARGIVTVIRELDYETTQ AYQLTVNATDQDKTRPLSTL ANLAIIITDVQDMDPIFINL PYSTNIYEHSPPGTTVRIIT AIDQDKGRPRG |
Tissue Specificity | Particularly strong expression in the retina. Found also in the cochlea. |
Function | Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells. CDH23 is required for establishing and/or maintaining the proper organization of the stereocilia bundle of hair cells in the cochlea and the vestibule during late embryonic/early postnatal development. It is part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal hearing. |
Protein Name | Cadherin-23 Otocadherin |
Database Links | Reactome: R-HSA-9662360 Reactome: R-HSA-9662361 |
Cellular Localisation | Cell Membrane Single-Pass Type I Membrane Protein |
Alternative Antibody Names | Anti-Cadherin-23 antibody Anti-Otocadherin antibody Anti-CDH23 antibody Anti-KIAA1774 antibody Anti-KIAA1812 antibody Anti-UNQ1894 antibody Anti-PRO4340 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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