Anti-FGB antibody (30-300 aa) [1F9] (STJ98070) STJ98070|產品目錄|代理商|上海91麻豆福利视频网生物科技有限公司

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產品名稱：Anti-FGB antibody (30-300 aa) [1F9] (STJ98070)
產品型號：STJ98070
產品廠商：ST john's laboratory
產品文檔：

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簡單介紹：

Anti-FGB antibody (30-300 aa) [1F9] (STJ98070)

詳情介紹：

Host:	Mouse
Applications:	WB/ELISA
Reactivity:	Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Mouse monoclonal antibody anti-Fibrinogen beta chain (30-300 aa) is suitable for use in Western Blot and ELISA research applications.

Clonality:	Monoclonal
Clone ID:	1F9
Conjugation:	Unconjugated
Isotype:	IgG1
Formulation:	Liquid in PBS containing 0.03% Sodium Azide, 0.5% BSA, 50% Glycerol.
Purification:	Affinity purification
Dilution Range:	WB 1:500-1:2000 ELISA 1:10000
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	FGB
Gene ID:	2244
Uniprot ID:	FIBB_HUMAN
Immunogen Region:	30-300 aa
Specificity:	Fibrinogen Beta Monoclonal Antibody detects endogenous levels of Fibrinogen Beta protein.
Immunogen:	Purified recombinant fragment of human Fibrinogen Beta (aa30-300) expressed in E. Coli.

Post Translational Modifications	Conversion of fibrinogen to fibrin is triggered by thrombin, which cleaves fibrinopeptides A and B from alpha and beta chains, and thus exposes the N-terminal polymerization sites responsible for the formation of the soft clot. The soft clot is converted into the hard clot by factor XIIIA which catalyzes the epsilon-(gamma-glutamyl)lysine cross-linking between gamma chains (stronger) and between alpha chains (weaker) of different monomers.
Function	Cleaved by the protease thrombin to yield monomers which, together with fibrinogen alpha (FGA) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the antibacterial immune response via both innate and T-cell mediated pathways.
Protein Name	Fibrinogen Beta Chain Cleaved Into - Fibrinopeptide B - Fibrinogen Beta Chain
Database Links	Reactome: R-HSA-114608 Reactome: R-HSA-1236974 Reactome: R-HSA-140875 Reactome: R-HSA-166058 Reactome: R-HSA-216083 Reactome: R-HSA-354192 Reactome: R-HSA-354194 Reactome: R-HSA-372708 Reactome: R-HSA-5602498 Reactome: R-HSA-5603041 Reactome: R-HSA-5674135 Reactome: R-HSA-5686938 Reactome: R-HSA-6802946 Reactome: R-HSA-6802948 Reactome: R-HSA-6802952 Reactome: R-HSA-6802955 Reactome: R-HSA-9649948 Reactome: R-HSA-9656223
Cellular Localisation	Secreted
Alternative Antibody Names	Anti-Fibrinogen Beta Chain Cleaved Into - Fibrinopeptide B - Fibrinogen Beta Chain antibody Anti-FGB antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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產品名稱：Anti-FGB antibody (30-300 aa) [1F9] (STJ98070)