產品詳情
簡單介紹：
Anti-CDK7 antibody (47-58) (STJ73141)
詳情介紹：
| Host: | Goat |
| Applications: | Pep-ELISA/WB |
| Reactivity: | Human/Mouse/Rat/Dog/Cow |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Goat polyclonal antibody anti-CDK7 (47-58) is suitable for use in ELISA and Western Blot research applications. |
| Clonality: | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: | 0.5 mg/mL |
| Dilution Range: | WB-0.3-1µg/ml ELISA-antibody detection limit dilution 1:128000. |
| Storage Instruction: | Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: | CDK7 |
| Gene ID: | 1022 |
| Uniprot ID: | CDK7_HUMAN |
| Immunogen Region: | 47-58 |
| Accession Number: | NP_001790.1 |
| Immunogen Sequence: | HRSEAKDGINRT |
| Post Translational Modifications | Phosphorylation of Ser-164 during mitosis inactivates the enzyme. Phosphorylation of Thr-170 is required for activity. Phosphorylated at Ser-164 and Thr-170 by CDK2. |
| Function | Serine/threonine kinase involved in cell cycle control and in RNA polymerase II-mediated RNA transcription. Cyclin-dependent kinases (CDKs) are activated by the binding to a cyclin and mediate the progression through the cell cycle. Each different complex controls a specific transition between 2 subsequent phases in the cell cycle. Required for both activation and complex formation of CDK1/cyclin-B during G2-M transition, and for activation of CDK2/cyclins during G1-S transition (but not complex formation). CDK7 is the catalytic subunit of the CDK-activating kinase (CAK) complex. Phosphorylates SPT5/SUPT5H, SF1/NR5A1, POLR2A, p53/TP53, CDK1, CDK2, CDK4, CDK6 and CDK11B/CDK11. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation, thus regulating cell cycle progression. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Phosphorylation of POLR2A in complex with DNA promotes transcription initiation by triggering dissociation from DNA. Its expression and activity are constant throughout the cell cycle. Upon DNA damage, triggers p53/TP53 activation by phosphorylation, but is inactivated in turn by p53/TP53.this feedback loop may lead to an arrest of the cell cycle and of the transcription, helping in cell recovery, or to apoptosis. Required for DNA-bound peptides-mediated transcription and cellular growth inhibition. |
| Protein Name | Cyclin-Dependent Kinase 7 39 Kda Protein Kinase P39 Mo15 Cdk-Activating Kinase 1 Cell Division Protein Kinase 7 Serine/Threonine-Protein Kinase 1 Tfiih Basal Transcription Factor Complex Kinase Subunit |
| Database Links | Reactome: R-HSA-112382 Reactome: R-HSA-113418 Reactome: R-HSA-167152 Reactome: R-HSA-167158 Reactome: R-HSA-167160 Reactome: R-HSA-167161 Reactome: R-HSA-167162 Reactome: R-HSA-167172 Reactome: R-HSA-167200 Reactome: R-HSA-167246 Reactome: R-HSA-427413 Reactome: R-HSA-5696395 Reactome: R-HSA-674695 Reactome: R-HSA-6781823 Reactome: R-HSA-6781827 Reactome: R-HSA-6782135 Reactome: R-HSA-6782210 Reactome: R-HSA-6796648 Reactome: R-HSA-6807505 Reactome: R-HSA-69202 Reactome: R-HSA-69231 Reactome: R-HSA-69273 Reactome: R-HSA-69656 Reactome: R-HSA-72086 Reactome: R-HSA-73762 Reactome: R-HSA-73772 Reactome: R-HSA-73776 Reactome: R-HSA-73779 Reactome: R-HSA-73863 Reactome: R-HSA-75953 Reactome: R-HSA-75955 Reactome: R-HSA-76042 Reactome: R-HSA-77075 Reactome: R-HSA-8939236 |
| Cellular Localisation | Nucleus Cytoplasm Perinuclear Region Colocalizes With Prkci In The Cytoplasm And Nucleus Translocates From The Nucleus To Cytoplasm And Perinuclear Region In Response To Dna-Bound Peptides |
| Alternative Antibody Names | Anti-Cyclin-Dependent Kinase 7 antibody Anti-39 Kda Protein Kinase antibody Anti-P39 Mo15 antibody Anti-Cdk-Activating Kinase 1 antibody Anti-Cell Division Protein Kinase 7 antibody Anti-Serine/Threonine-Protein Kinase 1 antibody Anti-Tfiih Basal Transcription Factor Complex Kinase Subunit antibody Anti-CDK7 antibody Anti-CAK antibody Anti-CAK1 antibody Anti-CDKN7 antibody Anti-MO15 antibody Anti-STK1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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