Anti-CDX2 antibody (Internal) (STJ70896) STJ70896-100|產品目錄|代理商|上海91麻豆福利视频网生物科技有限公司

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Anti-CDX2 antibody (Internal) (STJ70896)

詳情介紹：

Host:	Goat
Applications:	Pep-ELISA/WB/IHC
Reactivity:	Human/Mouse/Rat/Dog
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Goat polyclonal antibody anti-CDX2 (Internal) is suitable for use in ELISA, Western Blot and Immunohistochemistry research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA
Purification:	Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration:	0.5 mg/mL
Dilution Range:	WB-1-3µg/ml IHC-5µg/ml ELISA-antibody detection limit dilution 1:4000.
Storage Instruction:	Store at-20°C on receipt and minimise freeze-thaw cycles.

Gene Symbol:	CDX2
Gene ID:	1045
Uniprot ID:	CDX2_HUMAN
Immunogen Region:	Internal
Accession Number:	NP_001256.1
Specificity:	No cross-reactivity expected with CDX1 and 4
Immunogen Sequence:	EQLSPGGQRRNLCE

Post Translational Modifications	Ubiquitinated, leading to its degradation by the proteasome. Phosphorylation at Ser-60 reduces transactivation capacity. Phosphorylation at Ser-283 reduces transactivation capacity and also increases ubiquitin-dependent proteasome degradation.
Function	Transcription factor which regulates the transcription of multiple genes expressed in the intestinal epithelium. Binds to the promoter of the intestinal sucrase-isomaltase SI and activates SI transcription. Binds to the DNA sequence 5'-ATAAAAACTTAT-3' in the promoter region of VDR and activates VDR transcription. Binds to and activates transcription of LPH. Activates transcription of CLDN2 and intestinal mucin MUC2. Binds to the 5'-AATTTTTTACAACACCT-3' DNA sequence in the promoter region of CA1 and activates CA1 transcription. Important in broad range of functions from early differentiation to maintenance of the intestinal epithelial lining of both the small and large intestine. Binds preferentially to methylated DNA.
Protein Name	Homeobox Protein Cdx-2 Cdx-3 Caudal-Type Homeobox Protein 2
Database Links	Reactome: R-HSA-381771
Cellular Localisation	Nucleus
Alternative Antibody Names	Anti-Homeobox Protein Cdx-2 antibody Anti-Cdx-3 antibody Anti-Caudal-Type Homeobox Protein 2 antibody Anti-CDX2 antibody Anti-CDX3 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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產品名稱：Anti-CDX2 antibody (Internal) (STJ70896)