產品詳情
簡單介紹：
Anti-FOXA2 antibody [7H4B7] (STJ98083)
詳情介紹：
| Host: | Mouse |
| Applications: | WB/IHC/IF/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Mouse monoclonal antibody anti-Hepatocyte nuclear factor 3-beta is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications. |
| Clonality: | Monoclonal |
| Clone ID: | 7H4B7 |
| Conjugation: | Unconjugated |
| Isotype: | IgG1 |
| Formulation: | Liquid in PBS containing 0.03% Sodium Azide, 0.5% BSA, 50% Glycerol. |
| Purification: | Affinity purification |
| Dilution Range: | WB 1:500-1:2000 IHC 1:200-1:1000 ELISA 1:10000 IF 1:50-200 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | FOXA2 |
| Gene ID: | 3170 |
| Uniprot ID: | FOXA2_HUMAN |
| Specificity: | FoxA2 Monoclonal Antibody detects endogenous levels of FoxA2 protein. |
| Immunogen: | Purified recombinant fragment of FoxA2 expressed in E. Coli. |
| Function | Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'-ACAATTAGTTGTAGCTTCT-3'. In embryonic development is required for notochord formation. Involved in the development of multiple endoderm-derived organ systems such as the liver, pancreas and lungs.FOXA1 and FOXA2 seem to have at least in part redundant roles. Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis.regulates the expression of genes important for glucose sensing in pancreatic beta-cells and glucose homeostasis. Involved in regulation of fat metabolism. Binds to fibrinogen beta promoter and is involved in IL6-induced fibrinogen beta transcriptional activation. |
| Protein Name | Hepatocyte Nuclear Factor 3-Beta Hnf-3-Beta Hnf-3b Forkhead Box Protein A2 Transcription Factor 3b Tcf-3b |
| Database Links | Reactome: R-HSA-210745 Reactome: R-HSA-9796292 Reactome: R-HSA-9823730 |
| Cellular Localisation | Nucleus Cytoplasm Shuttles Between The Nucleus And Cytoplasm In A Crm1-Dependent Manner In Response To Insulin Signaling Via Akt1 Is Exported From The Nucleus |
| Alternative Antibody Names | Anti-Hepatocyte Nuclear Factor 3-Beta antibody Anti-Hnf-3-Beta antibody Anti-Hnf-3b antibody Anti-Forkhead Box Protein A2 antibody Anti-Transcription Factor 3b antibody Anti-Tcf-3b antibody Anti-FOXA2 antibody Anti-HNF3B antibody Anti-TCF3B antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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