Anti-FOXK2 antibody (331-381) (STJA0006639) STJA0006639|產品目錄|代理商|上海91麻豆福利视频网生物科技有限公司

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產品名稱：Anti-FOXK2 antibody (331-381) (STJA0006639)
產品型號：STJA0006639
產品廠商：ST john's laboratory
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Anti-FOXK2 antibody (331-381) (STJA0006639)

詳情介紹：

Host:	Rabbit
Applications:	WB
Reactivity:	Human/Mouse
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-Forkhead box protein K2 (331-381) is suitable for use in Western Blot research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:	1 mg/mL
Dilution Range:	WB 1:1000-2000
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	FOXK2
Gene ID:	3607
Uniprot ID:	FOXK2_HUMAN
Immunogen Region:	331-381
Specificity:	This antibody detects endogenous levels of human FOXK2
Immunogen:	Synthesized peptide derived from human FOXK2 AA range: 331-381

Post Translational Modifications	Hyperphosphorylated during mitosis by CDK1 and, to a lower extent, CDK2. Phosphorylation at Ser-373 and Ser-428 affects stability by promoting degradation.
Function	Transcriptional regulator involved in different processes such as glucose metabolism, aerobic glycolysis and autophagy. Recognizes and binds the forkhead DNA sequence motif (5'-GTAAACA-3') and can both act as a transcription activator or repressor, depending on the context. Together with FOXK1, acts as a key regulator of metabolic reprogramming towards aerobic glycolysis, a process in which glucose is converted to lactate in the presence of oxygen. Acts by promoting expression of enzymes for glycolysis (such as hexokinase-2 (HK2), phosphofructokinase, pyruvate kinase (PKLR) and lactate dehydrogenase), while suppressing further oxidation of pyruvate in the mitochondria by up-regulating pyruvate dehydrogenase kinases PDK1 and PDK4. Probably plays a role in gluconeogenesis during overnight fasting, when lactate from white adipose tissue and muscle is the main substrate. Together with FOXK1, acts as a negative regulator of autophagy in skeletal muscle: in response to starvation, enters the nucleus, binds the promoters of autophagy genes and represses their expression, preventing proteolysis of skeletal muscle proteins. In addition to the 5'-GTAAACA-3' DNA motif, also binds the 5'-TGANTCA-3' palindromic DNA motif, and co-associates with JUN/AP-1 to activate transcription. Also able to bind to a minimal DNA heteroduplex containing a G/T-mismatch with 5'-TRTG/TNB-3' sequence. Binds to NFAT-like motifs (purine-rich) in the IL2 promoter. Positively regulates WNT/beta-catenin signaling by translocating DVL proteins into the nucleus. Also binds to HIV-1 long terminal repeat. May be involved in both positive and negative regulation of important viral and cellular promoter elements.
Protein Name	Forkhead Box Protein K2 G/T-Mismatch Specific Binding Protein Ngtbp Interleukin Enhancer-Binding Factor 1
Database Links	Reactome: R-HSA-5689603
Cellular Localisation	Nucleus Cytoplasm
Alternative Antibody Names	Anti-Forkhead Box Protein K2 antibody Anti-G/T-Mismatch Specific Binding Protein antibody Anti-Ngtbp antibody Anti-Interleukin Enhancer-Binding Factor 1 antibody Anti-FOXK2 antibody Anti-ILF antibody Anti-ILF1 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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產品名稱：Anti-FOXK2 antibody (331-381) (STJA0006639)