Anti-ERCC6 antibody (141-190 aa) (STJ92493) STJ92493|產品目錄|代理商|上海91麻豆福利视频网生物科技有限公司

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產品名稱：Anti-ERCC6 antibody (141-190 aa) (STJ92493)
產品型號：STJ92493
產品廠商：ST john's laboratory
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Anti-ERCC6 antibody (141-190 aa) (STJ92493)

詳情介紹：

Host:	Rabbit
Applications:	IHC/IF/ELISA
Reactivity:	Human/Rat/Mouse
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-DNA excision repair protein ERCC-6 (141-190 aa) is suitable for use in Immunohistochemistry, Immunofluorescence and ELISA research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:	1 mg/mL
Dilution Range:	IHC 1:100-1:300 ELISA 1:40000 IF 1:50-200
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	ERCC6
Gene ID:	2074
Uniprot ID:	ERCC6_HUMAN
Immunogen Region:	141-190 aa
Specificity:	CSB Polyclonal Antibody detects endogenous levels of CSB protein.
Immunogen:	The antiserum was produced against synthesized peptide derived from the human ERCC6 at the amino acid range 141-190

Function	Essential factor involved in transcription-coupled nucleotide excision repair which allows RNA polymerase II-blocking lesions to be rapidly removed from the transcribed strand of active genes. Upon DNA-binding, it locally modifies DNA conformation by wrapping the DNA around itself, thereby modifying the interface between stalled RNA polymerase II and DNA. It is required for transcription-coupled repair complex formation. It recruits the CSA complex (DCX(ERCC8) complex), nucleotide excision repair proteins and EP300 to the sites of RNA polymerase II-blocking lesions. Plays an important role in regulating the choice of the DNA double-strand breaks (DSBs) repair pathway and G2/M checkpoint activation.DNA-dependent ATPase activity is essential for this function. Regulates the DNA repair pathway choice by inhibiting non-homologous end joining (NHEJ), thereby promoting the homologous recombination (HR)-mediated repair of DSBs during the S/G2 phases of the cell cycle. Mediates the activation of the ATM- and CHEK2-dependent DNA damage responses thus preventing premature entry of cells into mitosis following the induction of DNA DSBs. Acts as a chromatin remodeler at DSBs.DNA-dependent ATPase-dependent activity is essential for this function. Remodels chromatin by evicting histones from chromatin flanking DSBs, limiting RIF1 accumulation at DSBs thereby promoting BRCA1-mediated HR. Required for stable recruitment of ELOA and CUL5 to DNA damage sites. Involved in UV-induced translocations of ERCC8 to the nuclear matrix. Essential for neuronal differentiation and neuritogenesis.regulates transcription and chromatin remodeling activities required during neurogenesis.
Protein Name	Dna Excision Repair Protein Ercc-6 Atp-Dependent Helicase Ercc6 Cockayne Syndrome Protein Csb
Database Links	Reactome: R-HSA-427389 Reactome: R-HSA-5250924 Reactome: R-HSA-6781823 Reactome: R-HSA-6781827 Reactome: R-HSA-6782135 Reactome: R-HSA-6782210 Reactome: R-HSA-73762
Cellular Localisation	Nucleus
Alternative Antibody Names	Anti-Dna Excision Repair Protein Ercc-6 antibody Anti-Atp-Dependent Helicase Ercc6 antibody Anti-Cockayne Syndrome Protein Csb antibody Anti-ERCC6 antibody Anti-CSB antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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產品名稱：Anti-ERCC6 antibody (141-190 aa) (STJ92493)