產品詳情
簡單介紹:
Anti-FABP5 antibody (1-135) (STJ11100060)
詳情介紹:
Host: | Rabbit |
Applications: | WB |
Reactivity: | Human/Mouse |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description: | Rabbit polyclonal antibody anti-FABP5 (1-135) is suitable for use in Western Blot research applications. |
Clonality: | Polyclonal |
Conjugation: | Unconjugated |
Isotype: | IgG |
Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
Purification: | Affinity purification |
Dilution Range: | WB 1:500-1:2000 |
Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Gene Symbol: | FABP5 |
Gene ID: | 2171 |
Uniprot ID: | FABP5_HUMAN |
Immunogen Region: | 1-135 |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-135 of human FABP5 (NP_001435.1). |
Immunogen Sequence: | MATVQQLEGRWRLVDSKGFD EYMKELGVGIALRKMGAMAK PDCIITCDGKNLTIKTESTL KTTQFSCTLGEKFEETTADG RKTQTVCNFTDGALVQHQEW DGKESTITRKLKDGKLVVEC VMNNVTCTRIYEKVE |
Tissue Specificity | Keratinocytes.highly expressed in psoriatic skin. Expressed in brain gray matter. |
Function | Intracellular carrier for long-chain fatty acids and related active lipids, such as endocannabinoids, that regulate the metabolism and actions of the ligands they bind. In addition to the cytosolic transport, selectively delivers specific fatty acids from the cytosol to the nucleus, wherein they activate nuclear receptors. Delivers retinoic acid to the nuclear receptor peroxisome proliferator-activated receptor delta.which promotes proliferation and survival. May also serve as a synaptic carrier of endocannabinoid at central synapses and thus controls retrograde endocannabinoid signaling. Modulates inflammation by regulating PTGES induction via NF-kappa-B activation, and prostaglandin E2 (PGE2) biosesynthesis during inflammation. May be involved in keratinocyte differentiation. |
Protein Name | Fatty Acid-Binding Protein 5 Epidermal-Type Fatty Acid-Binding Protein E-Fabp Fatty Acid-Binding Protein - Epidermal Psoriasis-Associated Fatty Acid-Binding Protein Homolog Pa-Fabp |
Database Links | Reactome: R-HSA-163560 Reactome: R-HSA-5362517 Reactome: R-HSA-6798695 |
Cellular Localisation | Cytoplasm Nucleus Synapse Postsynaptic Density Secreted Localizes Primarily To The Cytoplasm Upon Certain Ligand Binding A Conformation Change Exposes A Nuclear Localization Motif And The Protein Is Transported Into Nucleus Secreted By Astrocytes But Not By Neurons |
Alternative Antibody Names | Anti-Fatty Acid-Binding Protein 5 antibody Anti-Epidermal-Type Fatty Acid-Binding Protein antibody Anti-E-Fabp antibody Anti-Fatty Acid-Binding Protein - Epidermal antibody Anti-Psoriasis-Associated Fatty Acid-Binding Protein Homolog antibody Anti-Pa-Fabp antibody Anti-FABP5 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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