Anti-FADS1 antibody (100-200) (STJ118736) STJ118736|產品目錄|代理商|上海91麻豆福利视频网生物科技有限公司

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產品名稱：Anti-FADS1 antibody (100-200) (STJ118736)
產品型號：STJ118736
產品廠商：ST john's laboratory
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Anti-FADS1 antibody (100-200) (STJ118736)

詳情介紹：

Host:	Rabbit
Applications:	WB
Reactivity:	Human/Mouse/Rat
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-FADS1 (100-200) is suitable for use in Western Blot research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification:	Affinity purification
Dilution Range:	WB 1:500-1:2000
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	FADS1
Gene ID:	3992
Uniprot ID:	FADS1_HUMAN
Immunogen Region:	100-200
Immunogen:	A synthetic peptide corresponding to a sequence within amino acids 100-200 of human FADS1 (NP_037534.3).
Immunogen Sequence:	YNISEFTRRHPGGSRVISHY AGQDATDPFVAFHINKGLVK KYMNSLLIGELSPEQPSFEP TKNKELTDEFRELRATVERM GLMKANHVFFLLYLLHILLL D

Tissue Specificity	Widely expressed, with highest levels in liver, brain, adrenal gland and heart. Highly expressed in fetal liver and brain.
Function	Isoform 1: Acts as a front-end fatty acyl-coenzyme A (CoA) desaturase that introduces a cis double bond at carbon 5 located between a preexisting double bond and the carboxyl end of the fatty acyl chain. Involved in biosesynthesis of highly unsaturated fatty acids (HUFA) from the essential polyunsaturated fatty acids (PUFA) linoleic acid (LA) (18:2n-6) and alpha-linolenic acid (ALA) (18:3n-3) precursors. Specifically, desaturates dihomo-gamma-linoleoate (DGLA) (20:3n-6) and eicosatetraenoate (ETA) (20:4n-3) to generate arachidonate (AA) (20:4n-6) and eicosapentaenoate (EPA) (20:5n-3), respectively. As a rate limiting enzyme for DGLA (20:3n-6) and AA (20:4n-6)-derived eicosanoid biosesynthesis, controls the metabolism of inflammatory lipids like prostaglandin E2, critical for efficient acute inflammatory response and maintenance of epithelium homeostasis. Contributes to membrane phospholipid biosesynthesis by providing AA (20:4n-6) as a major acyl chain esterified into phospholipids. In particular, regulates phosphatidylinositol-4,5-bisphosphate levels, modulating inflammatory cytokine production in T-cells. Also desaturates (11E)-octadecenoate (trans-vaccenoate)(18:1n-9), a metabolite in the biohydrogenation pathway of LA (18:2n-6). Isoform 2: Does not exhibit any catalytic activity toward 20:3n-6, but it may enhance FADS2 activity.
Protein Name	Acyl-Coa 8-3-Desaturase Delta(5 Fatty Acid Desaturase D5d Delta(5 Desaturase Delta-5 Desaturase Fatty Acid Desaturase 1
Database Links	Reactome: R-HSA-1989781 Reactome: R-HSA-2046105 Reactome: R-HSA-2046106
Cellular Localisation	Isoform 1: Endoplasmic Reticulum Membrane Multi-Pass Membrane Protein Mitochondrion Isoform 2: Endoplasmic Reticulum Membrane
Alternative Antibody Names	Anti-Acyl-Coa antibody Anti-8-3-Desaturase antibody Anti-Delta(5 Fatty Acid Desaturase antibody Anti-D5d antibody Anti-Delta(5 Desaturase antibody Anti-Delta-5 Desaturase antibody Anti-Fatty Acid Desaturase 1 antibody Anti-FADS1 antibody Anti-FADSD5 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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產品名稱：Anti-FADS1 antibody (100-200) (STJ118736)