產品詳情
簡單介紹：
Anti-FADS2 antibody (1-444) (STJ112308)
詳情介紹：
| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Rabbit polyclonal antibody anti-FADS2 (1-444) is suitable for use in Western Blot research applications. |
| Clonality: | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.05% Proclin300, 50% Glycerol, pH7.3. |
| Purification: | Affinity purification |
| Dilution Range: | WB 1:500-1:1000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | FADS2 |
| Gene ID: | 9415 |
| Uniprot ID: | FADS2_HUMAN |
| Immunogen Region: | 1-444 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-444 of human FADS2 (NP_004256.1). |
| Immunogen Sequence: | MGKGGNQGEGAAEREVSVPT FSWEEIQKHNLRTDRWLVID RKVYNITKWSIQHPGGQRVI GHYAGEDATDAFRAFHPDLE FVGKFLKPLLIGELAPEEPS QDHGKNSKITEDFRALRKTA EDMNLFKTNHV |
| Tissue Specificity | Expressed in a wide array of tissues, highest expression is found in liver followed by brain, lung, heart, and retina. A lower level is found in breast tumor when compared with normal tissues.lowest levels were found in patients with poor prognostic index. |
| Function | Involved in the biosesynthesis of highly unsaturated fatty acids (HUFA) from the essential polyunsaturated fatty acids (PUFA) linoleic acid (LA) (18:2n-6) and alpha-linolenic acid (ALA) (18:3n-3) precursors, acting as a fatty acyl-coenzyme A (CoA) desaturase that introduces a cis double bond at carbon 6 of the fatty acyl chain. Catalyzes the first and rate limiting step in this pathway which is the desaturation of LA (18:2n-6) and ALA (18:3n-3) into gamma-linoleate (GLA) (18:3n-6) and stearidonate (18:4n-3), respectively. Subsequently, in the biosesynthetic pathway of HUFA n-3 series, it desaturates tetracosapentaenoate (24:5n-3) to tetracosahexaenoate (24:6n-3), which is then converted to docosahexaenoate (DHA)(22:6n-3), an important lipid for nervous system function. Desaturates hexadecanate (palmitate) to produce 6Z-hexadecenoate (sapienate), a fatty acid unique to humans and major component of human sebum, that has been implicated in the development of acne and may have potent antibacterial activity. It can also desaturate (11E)-octadecenoate (trans-vaccenoate, the predominant trans fatty acid in human milk) at carbon 6 generating (6Z,11E)-octadecadienoate. In addition to Delta-6 activity, this enzyme exhibits Delta-8 activity with slight biases toward n-3 fatty acyl-CoA substrates. |
| Protein Name | Acyl-Coa 6-Desaturase Delta(6 Fatty Acid Desaturase D6d Delta(6 Desaturase Delta-6 Desaturase Fatty Acid Desaturase 2 |
| Database Links | Reactome: R-HSA-2046105 Reactome: R-HSA-2046106 |
| Cellular Localisation | Endoplasmic Reticulum Membrane Multi-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Acyl-Coa 6-Desaturase antibody Anti-Delta(6 Fatty Acid Desaturase antibody Anti-D6d antibody Anti-Delta(6 Desaturase antibody Anti-Delta-6 Desaturase antibody Anti-Fatty Acid Desaturase 2 antibody Anti-FADS2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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