Anti-FBXW5 antibody (319-369 aa) (STJ193592) STJ193592|產品目錄|代理商|上海91麻豆福利视频网生物科技有限公司

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Anti-FBXW5 antibody (319-369 aa) (STJ193592)

詳情介紹：

Host:	Rabbit
Applications:	WB
Reactivity:	Human/Mouse/Rat
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-F-box/WD repeat-containing protein 5 (319-369 aa) is suitable for use in Western Blot research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:	1 mg/mL
Dilution Range:	WB 1:500-2000
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	FBXW5
Gene ID:	54461
Uniprot ID:	FBXW5_HUMAN
Immunogen Region:	319-369 aa
Specificity:	This antibody detects endogenous levels of FBXW5 at Human/Mouse/Rat
Immunogen:	Synthesized peptide derived from the human FBXW5 at the amino acid range 319-369

Function	Substrate recognition component of both SCF (SKP1-CUL1-F-box protein) and DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes. Substrate recognition component of the SCF(FBXW5) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of SASS6 during S phase, leading to prevent centriole reduplication. The SCF(FBXW5) complex also mediates ubiquitination and degradation of actin-regulator EPS8 during G2 phase, leading to the transient degradation of EPS8 and subsequent cell shape changes required to allow mitotic progression. Substrate-specific adapter of the DCX(FBXW5) E3 ubiquitin-protein ligase complex which mediates the polyubiquitination and subsequent degradation of TSC2. May also act as a negative regulator of MAP3K7/TAK1 signaling in the interleukin-1B (IL1B) signaling pathway.
Protein Name	F-Box/Wd Repeat-Containing Protein 5 F-Box And Wd-40 Domain-Containing Protein 5
Database Links	Reactome: R-HSA-390471 Reactome: R-HSA-8951664 Reactome: R-HSA-983168
Cellular Localisation	Cytoplasm
Alternative Antibody Names	Anti-F-Box/Wd Repeat-Containing Protein 5 antibody Anti-F-Box And Wd-40 Domain-Containing Protein 5 antibody Anti-FBXW5 antibody Anti-FBW5 antibody Anti-PP3971 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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產品名稱：Anti-FBXW5 antibody (319-369 aa) (STJ193592)