Anti-FEM1A antibody (100-300) (STJ118569) STJ118569|產品目錄|代理商|上海91麻豆福利视频网生物科技有限公司

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產品名稱：Anti-FEM1A antibody (100-300) (STJ118569)
產品型號：STJ118569
產品廠商：ST john's laboratory
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簡單介紹：

Anti-FEM1A antibody (100-300) (STJ118569)

詳情介紹：

Host:	Rabbit
Applications:	WB
Reactivity:	Human/Mouse
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-FEM1A (100-300) is suitable for use in Western Blot research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification:	Affinity purification
Dilution Range:	WB 1:500-1:2000
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	FEM1A
Gene ID:	55527
Uniprot ID:	FEM1A_HUMAN
Immunogen Region:	100-300
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 100-300 of human FEM1A (NP_061178.1).
Immunogen Sequence:	RSLLRRGASVNRTTRTNSTP LRAACFDGHLEVVRYLVGEH QADLEVANRHGHTCLMISCY KGHREIARYLLEQGAQVNRR SAKGNTALHDCAESGSLEIL QLLLGCKARMERDGYGMTPL LAASVTGHTNIVEYLIQEQP GQEQVAGGEAQPGLPQEDPS TSQGCAQPQGAPCCSSSPEE PLNGESYESCCPTSREAAVE A

Tissue Specificity	Present in macrophages derived from peripheral blood monocytes. Also present in atheromata (at protein level).
Post Translational Modifications	Phosphorylated.highly phosphorylated in myoblasts and myotubes. Phosphorylation at Ser-108 promotes PGE2-EP4-mediated inhibition of inflammation. Dephosphorylated by protein phosphatase 2A (PP2A).
Function	Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation. The C-degron recognized by the DesCEND pathway is usually a motif of less than ten residues and can be present in full-length proteins, truncated proteins or proteolytically cleaved forms. The CRL2(FEM1A) complex specifically recognizes proteins with an arginine at the C-terminus: recognizes and binds proteins ending with -Lys/Arg-Xaa-Arg and -Lys/Arg-Xaa-Xaa-Arg C-degrons, such as SIL1 or OR51B2, leading to their ubiquitination and degradation. Promotes ubiquitination and degradation of SLBP. Involved in PGE2-EP4-mediated inhibition of inflammation of macrophages via interaction with NFKB1 and PTGER4. Promotes inflammation in brain microglia through MAP2K4/MKK4-mediated signaling.
Protein Name	Protein Fem-1 Homolog A Fem1a Fem1-Alpha Prostaglandin E Receptor 4-Associated Protein
Database Links	Reactome: R-HSA-8951664
Cellular Localisation	Mitochondrion Cytoplasm
Alternative Antibody Names	Anti-Protein Fem-1 Homolog A antibody Anti-Fem1a antibody Anti-Fem1-Alpha antibody Anti-Prostaglandin E Receptor 4-Associated Protein antibody Anti-FEM1A antibody Anti-EPRAP antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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產品名稱：Anti-FEM1A antibody (100-300) (STJ118569)