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Anti-FEM1B antibody (STJA0008155) STJA0008155|產品目錄|代理商|上海91麻豆福利视频网生物科技有限公司
產品詳情

  • 產品名稱：Anti-FEM1B antibody (STJA0008155)

  • 產品型號：STJA0008155
  • 產品廠商：ST john's laboratory
  • 產品文檔：
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簡單介紹：
Anti-FEM1B antibody (STJA0008155)
詳情介紹：
Host: Rabbit
Applications: WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Protein fem-1 homolog B is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: FEM1B
Gene ID: 10116
Uniprot ID: FEM1B_HUMAN
Specificity: This antibody detects endogenous levels of FEM1B at Human, Mouse, Rat
Immunogen: Synthesized peptide derived from human FEM1B
Function Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation. The C-degron recognized by the DesCEND pathway is usually a motif of less than ten residues and can be present in full-length proteins, truncated proteins or proteolytically cleaved forms. The CRL2(FEM1B) complex specifically recognizes proteins ending with -Gly-Leu-Asp-Arg, such as CDK5R1, leading to their ubiquitination and degradation. Also acts as a regulator of the reductive stress response by mediating ubiquitination of reduced FNIP1: in response to reductive stress, the CRL2(FEM1B) complex specifically recognizes a conserved Cys degron in FNIP1 when this degron is reduced, leading to FNIP1 degradation and subsequent activation of mitochondria to recalibrate reactive oxygen species (ROS). Mechanistically, recognizes and binds reduced FNIP1 through two interface zinc ions, which act as a molecular glue that recruit reduced FNIP1 to FEM1B. Promotes ubiquitination of GLI1, suppressing GLI1 transcriptional activator activity. Promotes ubiquitination and degradation of ANKRD37. Promotes ubiquitination and degradation of SLBP. Involved in apoptosis by acting as a death receptor-associated protein that mediates apoptosis. Also involved in glucose homeostasis in pancreatic islet. May also act as an adapter/mediator in replication stress-induced signaling that leads to the activation of CHEK1.
Protein Name Protein Fem-1 Homolog B
Fem1b
Fem1-Beta
Fem-1-Like Death Receptor-Binding Protein Alpha
Fem-1-Like In Apoptotic Pathway Protein Alpha
F1a-Alpha
Database Links Reactome: R-HSA-8951664
Cellular Localisation Cytoplasm
Nucleus
In The Nucleus
The Protein Level Increased Slightly After Camptothecin (Cpt) Treatment
Associated With Chromatin
Alternative Antibody Names Anti-Protein Fem-1 Homolog B antibody
Anti-Fem1b antibody
Anti-Fem1-Beta antibody
Anti-Fem-1-Like Death Receptor-Binding Protein Alpha antibody
Anti-Fem-1-Like In Apoptotic Pathway Protein Alpha antibody
Anti-F1a-Alpha antibody
Anti-FEM1B antibody
Anti-F1AA antibody
Anti-KIAA0396 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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